184229-77-4

Upstream product

• 184229-76-3 Toluene-4-sulfonic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 111570-92-4 N⁶-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosine 
• 184229-75-2 N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Downstream Products

• 184229-78-5 N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 125443-94-9 N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 184229-79-6 N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Relevant academic research and scientific papers

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

DNA ligation by DNA topoisomerase I was investigated employing synthetic DNA substrates containing a single strand nick. Site-specific cleavage of the DNA by topoisomerase I in proximity to the nick resulted in uncoupling of the cleavage and ligation reac