184433-59-8

Upstream product

• 420-04-2 CYANAMID 
• 123-54-6 acetylacetone 
• 57-68-1 sulfadimesine 
• 53112-28-0 Pyrimethanil 

Downstream Products

• 15755-12-1 2-Acetamido-4,6-dimethylpyrimidin 
• 106270-42-2 N-benzyl-2-amino-4,6-dimethylpyrimidine 
• 53456-48-7 2-Benzoylamino-4,6-dimethyl-pyrimidin 
• 1766-81-0 1-(4,6-dimethyl-pyrimidin-2-yl)-3-(4-fluoro-phenyl)-urea 
• 6149-31-1 N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide 
• 123458-65-1 2-tosylamino-4,6-dimethylpyrimidine 
• 106472-36-0 N-(3,4-dichloro-phenyl)-N'-(4,6-dimethyl-pyrimidin-2-yl)-urea 
• 515-55-9 4-methoxy-benzenesulfonic acid-(4,6-dimethyl-pyrimidin-2-ylamide) 
• 50910-49-1 [4-(4,6-dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-carbamic acid ethyl ester 
• 875843-56-4 4-cyano-benzenesulfonic acid-(4,6-dimethyl-pyrimidin-2-ylamide) 
• 15231-64-8 2-Methylamino-4,6-dimethyl-pyrimidin 
• 7749-61-3 2-amino-5-chloro-4,6-dimethylpyrimidine 
• 53456-49-8 2-chloro-N-(4,6-dimethylpyrimidin-2-yl)acetamide 
• 88067-09-8 1-(4',6'-dimethylpyrimidin-2-yl)thiourea 

Relevant academic research and scientific papers

The performance and degradation mechanism of sulfamethazine from wastewater using IFAS-MBR

Sulfamethazine (SMZ) is an important sulfonamide antibiotic. Although the concentration in the environment is small, it is harmful. The drug residues can be transferred, transformed or accumulated, affecting the growth of animals and plants. In this study, the integrated fixed-film activated sludge membrane bioreactor (IFAS-MBR) were constructed to investigate the performance and degradation mechanism of SMZ. The addition of SMZ had a significant impact on the removal of the chemical oxygen demand (COD) and ammonia nitrogen (NH4 +-N). The optimal operating conditions were hydraulic retention time (HRT) at 10 h and solid retention time (SRT) at 80 d, respectively. On this basis, the effects of different SMZ concentrations on nutrient removal, degradation, and sludge characteristics were compared. The removal efficiency of SMZ increased with the increase of SMZ concentration. The maximum removal rate was as high as 87%. The SMZ dosage also had an obvious effect on sludge characteristics. As the SMZ concentration increased, the extracellular polymer substances (EPS) concentration and the membrane resistance both decreased, which were beneficial for the reduction of membrane fouling. Finally, seven kinds of SMZ biodegradation intermediates were identified, and the possible degradation pathways were speculated. The microbial community results showed that the microbial diversity and richness in the reactor decreased after adding SMZ to the influent. The relative abundance of Bacteroidetes, Actinobacteria, Saccharibacteria and Nitrospirae increased at the phylum level. Sphingobacteria and Betaproteobacteria became dominant species at the class level. The relative abundance of norank-p-Saccharibacteria and Nitrospirae increased significantly, and norank-p-Saccharibacteria may be the dominant bacteria for SMZ degradation.

Photolysis of sulfamethazine using UV irradiation in an aqueous medium

Although many studies have been focused on the photochemistry of antibiotics, the roles of reactive species in photolysis and the effects of dissolved substances on antibiotic photochemical behavior have been poorly examined. The photolytic behaviors of s

Synthesis of TiO2-Ag3PO4photocatalyst material with high adsorption capacity and photocatalytic activity: application in the removal of dyes and pesticides

The photocatalytic activity of TiO2can be enhanced by coupling it with other semiconductors and the semiconductor composites may find useful application in water treatment technologies. TiO2-Ag3PO4composites wer

Photolysis and photocatalytic decomposition of sulfamethazine antibiotics in an aqueous solution with TiO2

Photo-decomposition of sulfamethazine (SMT) involves photolytic and photo-catalytic reactions, which occur simultaneously. The relative contributions of these two reactions to the overall SMT photo-decompositions by TiO2 and the intermediates of SMT photo-decompositions were systematically examined with the effects of TiO2 loading, and the pH and the initial SMT concentrations in the solutions. The apparent rate constants of SMT photo-decomposition reactions, which were well described by the pseudo-first-order kinetic model, ranged from 0.24 to 1.61 h-1. The overall photo-decomposition efficiencies of 0.072 mM SMT were the highest at pH 5.5 with 0.5 g L-1 TiO2 due to the adsorption-induced photocatalytic decomposition of SMT on TiO2. However, the SMT photolysis occurred more rapidly at pH 10. Two reactive species of holes and hydroxyl radicals concurrently participated in the photocatalytic decomposition of SMT, and the latter dominated the oxidative reactions of SMT on TiO2. Eight intermediates of SMT photo-decomposition were determined using LC-MS. Their time-dependent distributions indicated that the photo-decomposition of SMT was triggered by hydroxylation on aniline and dimethylpyrimidinyl moieties, followed by the cleavage of the S-N bond of SMT. Our results illustrated that the intermediates with dimethylpyrimidinyl groups possess strong resistance to photo-decomposition and played a determinant role in the photo-decomposition of SMT.

Factors affecting sonolytic degradation of sulfamethazine in water

In this study, the major factors affecting sonolytic degradation of sulfamethazine (SMT), a typical pharmaceutically active compound, in water were evaluated. The factors tested included two operational parameters (i.e. initial SMT concentration and ultrasonic power), three dissolved gases (i.e. Ar, O 2 and N2), five most frequently found anions in water (NO3-,Cl-,SO42-,HCO3-andBr-), ferrous ion (Fe 2+), and four alcohols (methanol, ethanol, isopropyl alcohol, tert-butyl alcohol). Typically, the degradation rate was increased with the increasing initial SMT concentration and power. The degradation rate was accelerated in the presence of argon or oxygen, but inhibited by nitrogen. Effects of anions on the ultrasonic treatment were species-dependent. The SMT degradation rate was slightly inhibited by NO3-,Cl-,and,SO42- but significantly improved by HCO3-andBr-. The negative effects of alcohols acted as hydroxyl radicals scavengers with the following order: tert-butyl alcohol > isopropyl alcohol > ethanol > methanol. The synergetic effect of ferrous ion was mainly due to production of additional hydroxyl radicals (·OH) through Fenton chemistry. LC/MS/MS analysis indicated that the degradation of SMT by ultrasonic irradiation is mainly ascribed to ·OH oxidation. Of interest, although the SMT could be rapidly degraded by ultrasonic irradiation, the degradation products were rarely mineralized. For example, ～100% of 180 μM SMT was decomposed, but only 8.31% TOC was reduced, within 2 h at an irradiation frequency of 800 kHz and a power of 100 W. However, the products became much biodegradable (BOD 5/COD was increased from 0.04 to 0.45). Therefore, an aerobic biological treatment may be an appropriate post-treatment to further decompose the SMT degradation products.