53456-49-8Relevant articles and documents
Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics
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Page/Page column 21; 27-28, (2011/10/31)
Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.
Synthesis of Pyrrazoles and Pyrazolopyrimidines from 3-Arylsulfonylaminoacrylates
McFadden, Helen G.,Huppatz, John L.,Halladay, Peter K.
, p. 873 - 886 (2007/10/02)
3-Arylsulfonylaminopyrazole-4-carboxamides and -carboxylates were synthesized from 3-arylsulfonylamino-3-methylthiocyanoacrylate derivatives as potential herbicidal inhibitors of the enzyme acetohydroxyacetic acid synthase (AHAS). Some of these compounds