18446-94-1Relevant academic research and scientific papers
2,6,7 SUBSTITUTED PURINES AS HDM2 INHIBITORS
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Page/Page column 98, (2014/08/20)
The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
Directing Effects in Homogeneous Hydrogenation with PF6
Crabtree, Robert H.,Davis, Mark W.
, p. 2655 - 2661 (2007/10/02)
The presence of a ligating group, e.g., OH, CO2Me, C=O, or OMe, on an olefinic substrate is shown to direct the attack of the hydrogenation catalyst PF6/H2/CH2Cl2 from the face of the molecule containing the directing group.Isomerization is a minor side reaction in the cases studied.The origin of this effect is discussed and a model intermediate isolated.
