7133-05-3Relevant articles and documents
Immunomodulator
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Paragraph 0254-0256; 0259-0260, (2021/05/22)
The invention discloses an immunomodulator, and particularly relates to a compound for inhibiting IL-17A and application of the compound serving as the immunomodulator in preparation of drugs. The invention discloses application of a compound shown in a formula I or a stereoisomer thereof in preparation of medicines for inhibiting IL-17A, and provides a new choice for clinically screening and/or preparing medicines for treating diseases related to IL-17A activity.
Immunomodulator
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Paragraph 0118-0119; 0121, (2021/05/22)
The invention discloses an immunomodulator, and particularly relates to a compound for inhibiting IL-17A and application of the compound serving as the immunomodulator in preparation of drugs. The invention discloses application of a compound shown in a f
Methylene C(sp3)-H β,β′-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand
Bull, James A.,St John-Campbell, Sahra,White, Andrew J. P.
supporting information, (2020/03/10)
A hindered β-amino amide transient directing group effects di-trans-arylation of cyclohexanecarbaldehydes. The amide N-substituents are shown to affect yield and can enhance the rate of arylation compared with the α-amino acid. Addition of a pyridone ligand further enhanced reactivity. The reaction is successful for a range of aryl iodides, and various substituted cyclohexane carboxaldehydes, providing functionalized products from simple feedstocks. A mechanism is proposed evoking a transient enamine.
SPIROCYCLIC INDANE ANALOGUES AS IL-17 MODULATORS
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Page/Page column 66, (2020/02/06)
A series of substituted spirocyclic indane derivatives of Formula (I), and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory
FUNCTIONALISED AMINE DERIVATIVES AS IL-17 MODULATORS
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Page/Page column 68, (2020/07/07)
A series of functionalised amine derivatives of formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
SPIROCYCLIC INDOLINES AS IL-17 MODULATORS
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Page/Page column 94, (2019/01/07)
A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
Substituted Imidazopyridines as HDM2 Inhibitors
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, (2014/07/08)
The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
2,6,7 SUBSTITUTED PURINES AS HDM2 INHIBITORS
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Page/Page column 98, (2014/08/20)
The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
IMIDAZOPYRROLIDINONE COMPOUNDS
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, (2013/08/15)
The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
SELECTIVE OXIDATION OF SATURATED HYDROCARBONS AT SECONDARY POSITIONS
Barton, Derek H. R.,Boivin, Jean,Ozbalik, Nubar,Schwartzentruber, Kathy M.
, p. 4219 - 4222 (2007/10/02)
The selectivity in the oxidation of saturated hydrocarbons by oxygen in pyridine-acetic acid in presence of an iron catalyst and zinc is strongly dependant on the oxygenation of the reaction mixture; using air and slow stirring, it is possible to attack a