53226-42-9

Basic information

• Product Name: N-cyclopentylbenzamide
• Synonyms: N-cyclopentylbenzamide
• CAS NO: 53226-42-9
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.2536
• Mol File: 53226-42-9.mol
• Article Data: 37

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-cyclopentylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclopentylbenzamide(53226-42-9)
• EPA Substance Registry System: N-cyclopentylbenzamide(53226-42-9)

Safety Data

• Hazardous Substances Data: 53226-42-9(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 1003-03-8 Cyclopentamine 
• 96-41-3 Cyclopentanol 
• 100-47-0 benzonitrile 
• 930-28-9 cyclopentyl chloride 
• 123-75-1 pyrrolidine 
• 82776-73-6 N-Cyclopentyl-N-(pyridine-2-carbonyl)-benzamide 
• 82776-77-0 N-Cyclopentyl-N-(4-pyrrolidin-1-yl-pyridine-2-carbonyl)-benzamide 
• 82776-75-8 N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide 
• 106-49-0 p-toluidine 
• 78607-65-5 N-benzoyl-2-aza-3-oxabicyclo(2.2.1)heptane 
• 18762-60-2 6-benzoyl-6-azabicyclo<3.1.0>hexane 
• 65-85-0 benzoic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1846-28-2 5-methyl-2,4,6-triphenylpyrimidine 
• 88123-59-5 5-ethyl-2,4,6-triphenylpyrimidine 
• 14277-91-9 tetraphenyl-2,4,5,6 pyrimidine 
• 1666-86-0 2,4,6-triphenylpyrimidine 

Relevant articles and documents

UV-Light-Induced N-Acylation of Amines with α-Diketones

Herein, we develop a mild method for N-acylation of primary and secondary amines with α-diketones induced by ultraviolet (UV) light. Forty-six examples with various functional groups are explored at room temperature with irradiation by three 26 W UV lamps (350-380 nm). The yield reaches 97%. The gram scale experiment product yield is 76%. Moreover, this system can be applied to the synthesis of several amino acid derivatives. Mechanistic studies show that benzoin is generated in situ from benzil under UV irradiation.

Two-step continuous flow synthesis of amide via oxidative amidation of methylarene

A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide.

Metal-Free C-N or C-C Bond Cleavages of α-Azido Ketones: An Oxidative-Amidation Strategy for the Synthesis of α-Ketothioamides and Amides

A novel metal-free oxidative-amidation strategy for the synthesis of α-ketothioamides and amides from α-azido ketones was developed. The C-H bond thionation of α-azido ketones with elemental sulfur could form α-ketothioacyl azide, which was then nucleophilically attacked by amines, causing the cleavage of the C-N bond to afford α-ketothioamides, while amides could be formed with the release of nitrogen gas and cyano anion in the presence of PhI(OAc)2 by selective C-C bond cleavage.