184644-72-2

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate is used as a synthetic intermediate for the development of pharmaceuticals, leveraging its chemical structure to contribute to the treatment of various diseases. Its specific role in drug synthesis allows for the creation of new medicinal compounds that can target and treat different health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate is utilized as a synthetic intermediate in the production of pesticides. Its chemical properties make it a candidate for the formulation of compounds that can effectively control, repel, or kill pests, thereby protecting crops and enhancing agricultural productivity.
It is crucial to exercise caution in the handling and application of Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate due to its potential health and environmental risks. Proper management and safety measures are essential to mitigate any adverse effects associated with this chemical compound.

Upstream product

• 59337-92-7 2-(carbomethoxy)thiophene-3-sulfonyl chloride 
• 166964-09-6 4-chloro-3-methyl-5-amino isoxazole 

Downstream Products

• 184036-18-8 N-(4-chloro-3-methyl-5-isoxazolyl)-2-{[2-cyano-4,5-(methylenedioxy)phenyl]aminocarbonyl}thiophene-3-sulfonamide 
• 184036-04-2 N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4,5-dimethoxy-2-methoxycarbonylphenyl)aminocarbonyl]thiophene-3-sulfonamide 
• 250651-14-0 3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate 
• 250651-13-9 ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate 

Relevant academic research and scientific papers

SITAXENTAN DERIVATIVE

A compound represented by formula (1-1) or (1-2), or a pharmacologically acceptable salt thereof retains the principal therapeutic effect of sitaxentan and has an improved CYP inhibitory effect: wherein R1 is a halogen atom, etc., R2 is a methyl group, etc., R3 is a C1-6 alkyl group, etc., and M is a group represented by: etc.

SUBSTITUTED THIOPHENES

Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides as selective endothelin receptor-A antagonists

We report here that N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides are potent and selective small molecule ET(A) receptor antagonists. The aryl group was subjected to extensive structural modification. With monosubstitution, the para

2-aryloxycarbonylthiophene-3-sulfonamides highly potent and ET(A) selective endothelin receptor antagonists

A series of 2-aryloxycarbonylthiophene-3-sulfonamides were synthesized and evaluated to determine their antagonistic activity at the endothelin receptors. N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy) phenoxycarbonyl]thiophene-3-sulfonamide was identified as a highly selective, potent (IC50= 8.3 nM) and low molecular weight nonpeptide antagonist.