184644-72-2

Basic information

• Product Name: Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate
• Synonyms: Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate;3-[[(4-Chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
• CAS NO: 184644-72-2
• Molecular Formula: C10H9ClN2O5S2
• Molecular Weight: 336.77186
• Mol File: 184644-72-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.602±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate(184644-72-2)
• EPA Substance Registry System: Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate(184644-72-2)

Safety Data

• Hazardous Substances Data: 184644-72-2(Hazardous Substances Data)

Usage

General Description

Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate is a chemical compound consisting of a methyl ester attached to a thiophene-2-carboxylate group, with a sulfaMoyl substituent attached to the thiophene ring. It also contains a chloro-substituted 3-Methylisoxazol-5-yl group. Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate is commonly used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals, with potential applications in the treatment of various diseases and as a pesticide. However, it is important to handle and use this chemical with care, as it may pose health and environmental risks if not managed properly.

Upstream product

• 59337-92-7 2-(carbomethoxy)thiophene-3-sulfonyl chloride 
• 166964-09-6 4-chloro-3-methyl-5-amino isoxazole 

Downstream Products

• 184036-18-8 N-(4-chloro-3-methyl-5-isoxazolyl)-2-{[2-cyano-4,5-(methylenedioxy)phenyl]aminocarbonyl}thiophene-3-sulfonamide 
• 184036-04-2 N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4,5-dimethoxy-2-methoxycarbonylphenyl)aminocarbonyl]thiophene-3-sulfonamide 
• 250651-14-0 3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate 
• 250651-13-9 ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate 

Relevant articles and documents

SITAXENTAN DERIVATIVE

A compound represented by formula (1-1) or (1-2), or a pharmacologically acceptable salt thereof retains the principal therapeutic effect of sitaxentan and has an improved CYP inhibitory effect: wherein R1 is a halogen atom, etc., R2 is a methyl group, etc., R3 is a C1-6 alkyl group, etc., and M is a group represented by: etc.

Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides as selective endothelin receptor-A antagonists

We report here that N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides are potent and selective small molecule ET(A) receptor antagonists. The aryl group was subjected to extensive structural modification. With monosubstitution, the para