184686-18-8

Upstream product

• 65-85-0 benzoic acid 
• 186750-51-6 (S)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 124506-30-5 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene 

Downstream Products

• 124409-98-9 (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 

Relevant academic research and scientific papers

A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction

A convenient procedure for preparation of the title compound of ≤ 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.

Process for preparation of (-)3(S)-methylbenzoxazine derivative

A process for preparing (-)3(S)-methylbenzoxazine derivative of formula (I) comprising the steps of reacting the compound of formula (II) with benzoic acid, triphenylphosphine and diethyl azodicarboxylate in an organic solvent to obtain the compound of fo