124409-98-9

Upstream product

• 184686-18-8 (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline 
• 82419-32-7 3,4-difluoro-2-(2-oxopropyloxy)nitrobenzene 
• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 124409-94-5 2,3-difluoro-6-nitro{[(R)-2-hydroxypropyl]oxy}benzene 
• 186750-51-6 (S)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 124506-30-5 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene 

Downstream Products

• 106939-42-8 (S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine 

Relevant academic research and scientific papers

Chemoenzymatic Asymmetric Synthesis of 1,4-Benzoxazine Derivatives: Application in the Synthesis of a Levofloxacin Precursor

A versatile and general route has been developed for the asymmetric synthesis of a wide family of 3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazines bearing different pattern substitutions in the aromatic ring. Whereas hydrolases were not suitable for resoluti

Process for preparation of (-)3(S)-methylbenzoxazine derivative

A process for preparing (-)3(S)-methylbenzoxazine derivative of formula (I) comprising the steps of reacting the compound of formula (II) with benzoic acid, triphenylphosphine and diethyl azodicarboxylate in an organic solvent to obtain the compound of fo

A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction

A convenient procedure for preparation of the title compound of ≤ 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.