124506-30-5

Basic information

• Product Name: 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene
• Synonyms: 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene
• CAS NO: 124506-30-5
• Molecular Weight: 233.172
• Mol File: 124506-30-5.mol

Chemical Properties

• CAS DataBase Reference: 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene(124506-30-5)
• EPA Substance Registry System: 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene(124506-30-5)

Safety Data

• Hazardous Substances Data: 124506-30-5(Hazardous Substances Data)

Upstream product

• 82419-32-7 3,4-difluoro-2-(2-oxopropyloxy)nitrobenzene 
• 124410-01-1 (S)-(-)-3,4-difluoro-2-[2-(2-tetrahydropyranyloxy)propoxy]nitrobenzene 
• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 771-69-7 2,3,4-trifluoronitrobenzene 

Downstream Products

• 186750-51-6 (S)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 129798-16-9 (S)-1-(2,3-difluro-6-nitrophenoxy)propan-2-yl methanesulfonate 
• 124409-98-9 (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 184686-18-8 (R) (-)-3,4-difluoro-2-(2-benzoyloxypropoxy)aniline 

Relevant articles and documents

Chemoenzymatic Asymmetric Synthesis of 1,4-Benzoxazine Derivatives: Application in the Synthesis of a Levofloxacin Precursor

A versatile and general route has been developed for the asymmetric synthesis of a wide family of 3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazines bearing different pattern substitutions in the aromatic ring. Whereas hydrolases were not suitable for resoluti

A facile synthesis of (S)-(-)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine by zinc chloride assisted Mitsunobu cyclization reaction

A convenient procedure for preparation of the title compound of ≤ 99% ee starting from 1-(2,3-difluoro-6-nitrophenoxy)-2-propanone (3) is presented. The key reaction is the intramolecular cyclization reaction in the presence of zinc chloride.

Propoxybenzene derivatives and process for preparing the same

Propoxybenzene derivatives represented by the following formula STR1 wherein Ra represents a nitro group, an amino group which may have a protecting group or an --NHCH=C(COO--C1-6 -Alkyl)2 group, Rb represents a hydrogen atom, a protecting group for the hydroxyl group or a substituted sulfonyl group and Xa and Xb, which may be the same or different, each represents a halogen atom, and processes for preparation thereof are disclosed. These derivatives are useful in preparing antibacterial agents.

Optically active benzoxazines and bezothiazines and a process for their stereospecific preparation

Optically active 7,8-difluoro-3,4-dihydro-3--methyl-2H-[1,4]benzoxazines and 7,8-difluoro-3,4-dihydro-2--methyl-2H-[1,4]benzoxazines and the corresponding benzothiazines of formula III, where, one of the substituents R1, R2, R3 and R4 is CH2OH or -CH2Z, the remaining being hydrogen, X denotes fluoro, chloro, methyl or hydrogen, Y is oxygen or sulfur and Z is hydrogen, fluoro or protected hydroxyl are obtained as the stereochemically pure products of a stereospecific synthesis using a 3,4-difluoronitrobenzene substituted with a stereochemically pure 2-(1-hydroxyisopropoxy), 2-(2--hydroxypropoxy), 2-(1-hydroxyisopropylthio) or 2-(2--hydroxypropylthio) substituent. The obtained compounds are suited for the production of optically active pyridobenzoxazines and pyridobenzothiazines, among which are useful antibacterial optically active quinolones, particularly (S)-(-)-ofloxacin.