185223-88-5

Basic information

• Product Name: Phenol, 4-[1-(4-bromophenyl)-2-phenyl-1-butenyl]-
• CAS NO: 185223-88-5
• Molecular Formula: C22H19BrO
• Molecular Weight: 379.296
• Mol File: 185223-88-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 4-[1-(4-bromophenyl)-2-phenyl-1-butenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-[1-(4-bromophenyl)-2-phenyl-1-butenyl]-(185223-88-5)
• EPA Substance Registry System: Phenol, 4-[1-(4-bromophenyl)-2-phenyl-1-butenyl]-(185223-88-5)

Safety Data

• Hazardous Substances Data: 185223-88-5(Hazardous Substances Data)

Upstream product

• 960245-06-1 1-(4-bromophenyl)-1-(4-methoxyphenyl)-2-phenylbut-1-ene 
• 100-66-3 methoxybenzene 
• 693818-58-5 4-(4-bromophenyl)-4-(4-methoxyphenyl)-3-phenylbut-1-ene 
• 4369-50-0 4-hydroxyphenyl-(4-bromo-phenyl)-methanone 
• 93-55-0 1-phenyl-propan-1-one 
• 586-75-4 4-chlorobenzoyl chloride 
• 54118-75-1 4-bromo-4'-methoxybenzophenone 

Downstream Products

• 116057-69-3 trans-4-Bromotamoxifen 
• 116057-71-7 cis-4-Bromotamoxifen 

Relevant articles and documents

Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities

Both selective estrogen receptor modulators and aromatase inhibitors are widely used for the treatment of breast cancer. Compounds with both aromatase inhibitory and estrogen receptor modulatory activities could have special advantages for treatment of br

Short-step synthesis of tamoxifen and its derivatives via the three-component coupling reaction and migration of the double bond

The anti-tumor agent, tamoxifen, is easily synthesized by the successive allylation of benzaldehyde and the Friedel-Crafts alkylation reaction of anisole with the intermediary homoallyl silyl ethers, followed by the migration of the double bond to form the desired tetra-substituted ethylenes. Several derivatives of tamoxifen are also produced according to a similar synthetic strategy.