185225-84-7

Usage

Uses

Used in Organic Synthesis:
Cyclopropanamine, 2-fluoro, (1S,2R)-, 4-methylbenzenesulfonate(9CI) is used as a reagent in organic synthesis for various chemical reactions. Its distinct structure and properties contribute to its versatility in creating a range of chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Cyclopropanamine, 2-fluoro, (1S,2R)-, 4-methylbenzenesulfonate(9CI) is utilized as an intermediate in the development of new drugs. Its unique configuration and functional groups make it a promising candidate for the synthesis of pharmaceutically active compounds.
Used in Agrochemical Industry:
Cyclopropanamine, 2-fluoro, (1S,2R)-, 4-methylbenzenesulfonate(9CI) also finds application in the agrochemical industry, where it serves as an intermediate in the synthesis of agrochemicals. Its properties allow for the creation of compounds with potential pesticidal or herbicidal activity.
Used in Drug Development:
Cyclopropanamine, 2-fluoro, (1S,2R)-, 4-methylbenzenesulfonate(9CI) is employed in the development of new drugs and chemical compounds. Its potential applications in medicinal chemistry make it a valuable asset in the discovery and synthesis of novel therapeutic agents.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 142977-51-3 (4R,5S)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5-diphenyl-oxazolidin-2-one 
• 156481-81-1 (R)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5,5-triphenyl-oxazolidin-2-one 
• 598-67-4 1,1,2-tribromo-2-fluoroethane 
• 108-59-8 malonic acid dimethyl ester 
• 142977-41-1 benzyl N-diphenylmethyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 167073-09-8 tert-butyl N-[(1S,2R)-2-fluorocyclopropyl]carbamate 
• 127199-16-0 tert-butyl N-<(1R,2S)-2-fluorocyclopropyl>carbamate 
• 142977-39-7 benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>-N-(1-phenylethyl)carbamate 

Downstream Products

• 141042-21-9 (-)-cis-2-fluorocyclopropylamine hydrochloride 

Relevant academic research and scientific papers

Sitafloxacin three membered ring intermediate preparation method

The invention discloses a preparation method for a three-membered ring intermediate of sitafloxacin hydrate. The preparation method comprises the following steps: dimethyl malonate and 1,1,2-tribromo-2-fluoroethane react to synthesize a solid A, the solid A is subjected to debromination to prepare an oily liquid B, the oily liquid B is subjected to branched chain removal to prepare a solid C, the solid C is hydrolyzed to prepare a solid D, the solid D is subjected to chiral resolution with L-leucinamide and reduced to prepare a solid F, the solid F is introduced to an amino group and combined with p-toluenesulfonic acid to prepare the three-membered ring intermediate of sitafloxacin hydrate. The preparation method has fewer steps for preparing the three-membered ring intermediate of sitafloxacin hydrate, unnecessary isomer is separated by one step with the chiral resolution method, the product yield and purity are higher, and scale production is easier.

Method for preparing cis-1-amino-2-fluorocyclopropane

The invention provides a method for preparing cis-1-amino-2-fluorocyclopropane. A preparation process comprises 8 to 10 steps. A structural formula of the cis-1-amino-2-fluorocyclopropane is represented by a formula 1 shown in the description, and the form of benzene sulfonate or hydrochloride is relatively common. An important intermediate product, i.e., cis-fluoro-amine olefin 2 is synthesized. The method has the advantages that the consumption of diiodo-fluoromethane or dibromo-fluoromethane, which is expensive in price and causes heavy pollution in a raw material production process, is avoided; a cis triatomic ring is obtained through the cyclization of high-activity cis-olefin 2, and an absolute-configuration product can be obtained by only one-time resolution, so that the method has especially great advantages in the aspect of either economical efficiency of the raw materials, or the difficulty of resolution of isomers.

Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid

A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopro

Synthesis of cis-2-fluorocyclopropylamine by stereoselective cyclopropanation under phase-transfer conditions

cis-2-Fluorocyclopropylamine is stereoselectively synthesized by cyclopropanation of 3-aryl-2-vinyl-3-(methoxy)isoin-dol-1-one by treating dibromofluoromethane with saturated aqueous KOH solution in the presence of 18-crown-6 in dichloromethane, followed by removal of a bromine atom of the formed bromofluorocyclopropane derivative with Raney Ni, and successive three steps-deprotection procedures for generating an amino group on the cyclopropane ring.

Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution

The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul

Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 2. Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine

The title synthesis was achieved by featuring diastereoface-selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone and its related compounds, the chiral conformationally rigid N-vinylcarbamates, with zinc-monofluorocarbenoid, followed

Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine, the Key Intermediate of the New Generation of Quinolonecarboxylic Acid, DU-6859

The title synthesis was achieved by featuring diastereoface selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone, the chiral and conformationally rigid N-vinylcarbamate, with zincmonofluorocarbenoid followed by hydrogenolysis of form

Synthesis and optical resolution of dl-cis-2-fluorocyclopropylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859

The title synthesis was accomplished by featuring highly cis-selective cyclopropanation of an N-vinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2-fluorocyclopropyl)carbamate. Optical resolution of dl-cis-2-fluoro