167073-09-8

Basic information

• Product Name: Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)
• Synonyms: Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)
• CAS NO: 167073-09-8
• Molecular Formula: C8H14FNO2
• Molecular Weight: 175.2006632
• Product Categories: N-BOC
• Mol File: 167073-09-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)(167073-09-8)
• EPA Substance Registry System: Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, (1S-trans)- (9CI)(167073-09-8)

Safety Data

• Hazardous Substances Data: 167073-09-8(Hazardous Substances Data)

Upstream product

• 167073-07-6 (1S,2R)-2-fluorocyclopropanecarboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 127199-13-7 (1R,2R)-(-)-cis-2-fluoro-cyclopropanecarboxylic acid 
• 156816-78-3 2-fluorocyclopropane-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 114152-95-3 (1R*,2S*)-2-fluorocyclopropylamine hydrochloride 
• 1493-01-2 fluorodiiodomethane 
• 7150-72-3 t-butyl N-vinylcarbamate 
• 114152-95-3 (1R*,2R*)-2-fluorocyclopropylamine hydrochloride 
• 127199-14-8 (1S,2S)-2-fluorocyclopropane-1-carboxylic acid 
• 141042-21-9 (-)-cis-2-fluorocyclopropylamine hydrochloride 
• 143062-85-5 (1R,2R)-2-fluorocyclopropylamine hydrochloride 

Downstream Products

• 143062-84-4 (1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt 
• 185225-84-7 (1S,2R)-2-fluorocyclopropylammonium p-toluenesulfonate 

Relevant articles and documents

Novel process for synthesizing 2 -fluorocyclopropylamine with high selectivity and asymmetric synthesis

A novel highly selective asymmetric synthesis process of 2 -fluorocyclopropylamine (Structural I). The method provided by the invention uses 1 - fluorine -1 - benzene (propylene) sulfonyl methane and chiral epichlorohydrin to construct chiral cyclopropane under basic conditions, and a new synthetic route not only achieves a special cis-trans selectivity, but also has a highly specific stereoselectivity. The synthesis route is efficient, the reaction condition is mild, the method is suitable for large industrial production in a green environment, 2 -fluorocyclopropylamine production cost is greatly reduced.

Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid

A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopro

Pyridonecarboxylic acid derivatives

Quinolone derivatives are known as synthetic antimicrobial agents having a condensed pyridonecarboxylic acid skeleton, and those having substituents on various replaceable positions of said skeleton are known. In particular, if diastereomers exist, there are 4 or more kinds of stereoisomers. A mixture of diastereomers is a mixture of isomers having different physical properties and is difficult to apply as a drug as such. The present invention provides an antimicrobial 1-(1,2-cis-2-fluorocyclopropyl)-substituted quinolone derivative represented by formula I shown below which, although involving diastereomers, consists of a single stereoisomer. STR1 wherein R1 represents a methyl group, a difluoromethyl group, etc.; R2 represents a saturated nitrogen-containing heterocyclic group; A represents C--X3 or a nitrogen atom; X1 and X2 each represents a halogen atom; and X3 and Z represent a hydrogen atom, etc.