185259-16-9Relevant academic research and scientific papers
Regioselective synthesis of pyridines and dihydropyridines derived from β-amino acids and aminophosphonates by reaction of N-vinylic phosphazenes with α,β-unsaturated ketones
Palacios, Francisco,Herrán, Esther,Rubiales, Gloria,Alonso, Concepción
, p. 5669 - 5676 (2007)
Reaction of N-vinylic phosphazenes with α,β-unsaturated ketones leads to the formation of pyridines derived from β-amino acids in a regioselective fashion. The use of functionalized enones derived from α-acylstyryl-carboxylates or -phosphonates affords biologically active asymmetrical and symmetrical dihydropyridines substituted with carboxylate or phosphonate groups including nitrendipine, felodipine, MRS 1097, and efonidipine analogs.
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: Selectivity for A3 receptors
Van Rhee, A. Michiel,Jiang, Ji-Long,Melman, Neli,Olah, Mark E.,Stiles, Gary L.,Jacobson, Kenneth A.
, p. 2980 - 2989 (2007/10/03)
1,4-Dihydropyridine and pyridine derivatives bound to three subtypes of adenosine receptors in the micromolar range. Affinity was determined in radioligand binding assays at rat brain A1 and A(2A) receptors using [3H]- (R)-PIA [[sup
