18600-61-8

Usage

Derivative of benzoic acid

It is a modified version of benzoic acid This means that 2-[(4-fluorobenzoyl)amino]benzoic acid is derived from the basic structure of benzoic acid, with additional functional groups added to the molecule.

Fluorine-substituted benzoyl group

A benzoyl group (C6H5CO) with a fluorine atom replacing one hydrogen atom This substitution introduces a halogen to the benzoyl group, which can affect the compound's reactivity, stability, and other properties.

Amino group attachment

The amino group (NH2) is attached to the benzoic acid molecule The presence of the amino group provides additional reactivity and allows for further functionalization of the compound.

Use as an intermediate

2-[(4-fluorobenzoyl)amino]benzoic acid can be used in the synthesis of pharmaceuticals and organic compounds This means that the compound can be used as a starting material or building block in the creation of more complex molecules, such as drugs and other organic compounds.

Potential applications in medicinal chemistry

The compound may have applications in the development of new drugs and therapies This suggests that 2-[(4-fluorobenzoyl)amino]benzoic acid could be an important component in the design and synthesis of new pharmaceuticals.

Valuable building block in organic synthesis

The structure and properties of the compound make it useful for creating new compounds with specific properties and functions This highlights the versatility of 2-[(4-fluorobenzoyl)amino]benzoic acid in organic chemistry, as it can be modified and used in various reactions to produce a wide range of compounds for industrial and research purposes.

Upstream product

• 18600-51-6 2-(4-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 
• 552-16-9 ortho-nitrobenzoic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 456-22-4 4-Fluorobenzoic acid 
• 782-17-2 2-(4-fluorophenyl)indole 
• 134-20-3 2-carbomethoxyaniline 
• 75541-83-2 methyl 2‐(4‐fluorobenzamido)benzoate 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 18600-51-6 2-(4-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 309925-98-2 4-bromo-N-[2-(4-fluoro-phenyl)-4-oxo-4H-quinazolin-3-yl]-benzamide 
• 389576-52-7 3-(4-bromobenzylamino)-2-(4-fluorophenyl)quinazolin-4(3H)-one 
• 388106-35-2 3-amino-2-(4-fluorophenyl)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes targeting HSP90-HER2 axis in breast cancer cells

Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes were designed as potential HSP90 inhibitors. A series of the compounds was synthesized by oximation of (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-ones followed by O-acylation with acylamid

A straightforward TBHP-mediated synthesis of 2-amidobenzoic acids from 2-arylindoles and their antimicrobial activity

A simple and highly efficient strategy has been developed for the synthesis of 2-amidobenzoic acids through the tert-butyl hydroperoxide (TBHP)-mediated oxygenation and sequential ring opening of 2-arylindoles in a one-pot fashion under metal-free aerobic conditions. The developed synthetic protocol is operationally simple, tolerates a wide range of functional groups, and is amenable to the gram-scale. Radical trapping experiments revealed that the reaction involves a radical pathway. The synthesized compounds (2a-s) were tested for in vitro antimicrobial activity. Among all screened compounds, 2d showed the maximum antibacterial activity against P. aerugunosa (ZOI = 17 mm, MIC = 32 μg mL-1) and compounds 2d and 2p showed the maximum (32 μg mL-1) antifungal activity against A. flavus and C. albicans.

Precursor-directed combinatorial biosynthesis of cinnamoyl, dihydrocinnamoyl, and benzoyl anthranilates in saccharomyces cerevisiae

Biological synthesis of pharmaceuticals and biochemicals offers an environmentally friendly alternative to conventional chemical synthesis. These alternative methods require the design of metabolic pathways and the identification of enzymes exhibiting ade

Cooperation of a Reductant and an Oxidant in One Pot to Synthesize Amides from Nitroarenes and Aldehydes

The reductant zinc powder and the oxidant sodium chlorate were used together in an appropriate ratio in one pot under ambient conditions, to provide an environmentally friendly, effective, and convenient method for the synthesis of aromatic amides in good yields from nitroarenes and aldehydes in the green solvents alcohol and water under atmospheric conditions. The good results indicate that reductants and oxidants with opposing properties can not only be used together without any adverse effects, but also improve the reaction yield through their cooperation.

Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity

Three series of sulfonamides incorporating long, bulky tails were obtained by applying synthetic strategies in which substituted anthranilic acids, quinazolines and aromatic sulfonamides have been used as starting materials. They incorporate long, bulky diamide-, 4-oxoquinazoline-3-yl- or quinazoline-4-yl moieties in their molecules, and were investigated for the inhibition of four physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic human (h) hCA I and II, as well as the transmembrane hCA IX and XII. Most of the new sulfonamides showed excellent inhibitory effects against the four isoforms, with KIs of 7.6-322 nM against hCA I, of 0.06-85.4 nM against hCA II; of 6.7-152 nM against hCA IX and of 0.49-237 nM against hCA XII; respectively. However no relevant isoform-selective behavior has been observed for any of them, although hCA II and XII, isoforms involved in glaucoma-genesis were the most inhibited ones. The structure-activity relationship for inhibiting the four CAs with these derivatives is discussed in detail.

QUINAZOLINONE MODULATORS OF TGR5

The present invention relates to quinazolinone compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.

QUINAZOLINONE MODULATORS OF TGR5

The present invention relates to quinazolinone compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.