186091-03-2

Upstream product

• 106-69-4 hexane-1,2,6-triol 
• 14739-10-7 4-(2,2-dimethyl-1,3-dioxolane-4-yl)-1-butanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 186091-08-7 2-azi-6-benzyloxy-1-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyloxy)hexane 
• 186091-10-1 2-azi-1-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyloxy)-7-oxa-9-thiadecane 
• 186091-09-8 2-azi-1-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyloxy)-6-hexanol 
• 186091-04-3 (+/-)-6-benzyloxy-1-triphenylmethyloxy-2-hexanol 
• 186091-05-4 6-benzyloxy-1-triphenylmethyloxy-2-hexanone 
• 188428-40-2 1,2-diacetoxy-6-benzyloxy-hexane 
• 186091-06-5 6-benzyloxy-1-hydroxy-2-hexanone 
• 186091-07-6 [3-(4-Benzyloxy-butyl)-3H-diazirin-3-yl]-methanol 
• 71998-68-0 (±)-6-benzyloxyhexan-1,2-diol 

Relevant academic research and scientific papers

Direct Synthesis of Free α-Amino Acids by Telescoping Three-Step Process from 1,2-Diols

A practical telescoping three-step process for the syntheses of α-amino acids from the corresponding 1,2-diols has been developed. This process enables the direct synthesis of free α-amino acids without any protection/deprotection step. This method was also effective for the preparation of a 15N-labeled α-amino acid. 1,2-Diols bearing α,β-unsaturated ester moieties afforded bicyclic α-amino acids through intramolecular [3 + 2] cycloadditions. A preliminary study suggests that the resultant α-amino acids are resolvable by aminoacylases with almost complete selectivity.

Syntheses of spacer-armed carbohydrate model compounds

Commercially available chemicals, such as diethylene glycol, 1,9-nonanediol, 9-decen-1-ol, 1,2,6-hexanetriol, and p-nitrophenol were used to prepare spacer-armed carbohydrate derivatives. Glycosides of D-glucose, N-acetyl-D-glucosamine and 3-O-methyl-D-glucose have been synthesized, carrying reactive groups at the end of the spacer-arms. These glycosides are capable of forming neoglycoproteins. When bromo sugars were reacted with highly apolar aglycones in the presence of mercuric cyanide or mercuric bromide, a considerable amount of '2-OH-compounds' (such as 9-hydroxynonyl 3,4,6-tri-O-acetyl-β-D-glucopyranoside) were formed. Some spacer-armed derivatives (such as 9,10-epoxydecyl β-D-glucopyranoside) are theoretically a mixture of diastereomers, but this fact does not mirror in the 1H and 13C NMR spectra.

Synthesis and application of α-D-mannosyl clusters as photoaffinity ligands for mannose-binding proteins: Concanavalin A as a model receptor

Mono-, di-, and tri-antennary α-D-mannopyranosyl derivatives were synthesized as oligosaccharide mimics. The compounds vary in the length of the acyclic aglyconic spacers linking, in the case of the di- and tri-antennary derivatives, the glycosyl endgroup