1861-48-9

Upstream product

• 4209-02-3 1-(4-bromophenyl)-2-chloroethan-1-one 
• 140-90-9 sodium O-ethyl dithiocarbonate 
• 140-89-6 potassium ethyl xanthogenate 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 105623-80-1 5-(4-bromo-benzoyl)-4-methylthio-1,3-dithiole-2-thione 
• 76173-08-5 1-(4-bromo-phenyl)-pent-4-en-1-one 
• 1198087-72-7 1-(4-bromophenyl)-2-(5-methylfuran-2-yl)ethan-1-one 
• 1562413-75-5 C₂₂H₃₅BrO₅S₂Si 
• 1509927-77-8 4-[3-(4-bromophenyl)-3-oxopropyl][1,3]dithietan-2-one 
• 40133-22-0 2-(4-bromophenyl)thiophene 
• 478800-93-0 dithiocarbonic acid S-{1-[3-(4-bromo-phenyl)-3-oxo-propyl]-heptyl} ester O-ethyl ester 
• 188999-93-1 Dithiocarbonic acid S-[4-(4-bromo-phenyl)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-oxo-butyl] ester O-ethyl ester 

Relevant academic research and scientific papers

Synthesis of pyrazolylvinyl ketones from furan derivatives

A new protocol for the synthesis of pyrazol-5-ylvinyl ketones, e.g. pyrazole-chalcones, employing furfuryl ketones as a triketone equivalent, has been developed. The reaction occurs under mild conditions and does not require the use of expensive materials

Efficient Synthesis of N-Benzyloxycarbonyl-2-aminoalkanesulfonyl Chlorides with Functionalized Side Chains

N-Benzyloxycarbonyl (Cbz)-protected 2-aminoalkanesulfonyl chlorides are useful building blocks for the synthesis of sulfonopeptides, which are receptor ligands and enzyme inhibitors, and are prepared by the coupling reaction of N-protected aminoalkanesulfonyl chlorides with amino acid or peptide esters. Various N-Cbz-protected 2-aminoalkanesulfonyl chlorides with functionalized side chains were synthesized through the radical addition of different xanthates to benzyl N-allylcarbamate and subsequent oxidative chlorination with tert-butyl hypochlorite under neutral conditions. A mechanism for the oxidative chlorination is proposed. This is a useful and convenient strategy for the synthesis of N-Cbz-protected 2-aminoalkanesulfonyl chlorides with diverse functionalized side-chains.

A simple method for the synthesis of furfuryl ketones and furylacetic acid derivatives

A simple preparative method has been developed for the synthesis of aryl(furfuryl) ketones, amides, and furylacetic acid esters, based on radical alkylation of furan derivatives at the α-position with O-ethyl(phenacyl)xanthogenates and phenacyl iodides in the presence of Fenton's reagent (H2O2/FeSO4·7H2O) in DMSO. The range of applicability and mechanisms for the formation of major and side products have been considered.

Flexible routes to thiophenes

Three convergent routes to thiophenes are described, hinging on the radical addition of α-xanthyl ketones to ethyl vinyl sulfide or to vinyl pivalate. The latter route ultimately proved to be the most versatile and efficient (61-94%).

SYNTEZY ZWIAZKOW O POTENCJALNYM DZIALANIU RADIOUCZULAJACYM. VIII. SYNTEZY ALKILOKSANTOGENIANOW 4-CHLORO- I 4-BROMOFENACYLOWYCH

In the frame-work of search for new potential radiosensitizers a series of novel 4-chloro- and 4-bromophenacyl alkylxanthates were synthetized by reacting 4-chloro- and 4-bromophenacyl bromide with potassium alkylxanthates, in which allyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, isopentyl, heksyl, heptyl, octyl, isooctyl, decyl, 3-tetrahydrofurfuryl, benzyl, phenylethyl and phenylpropyl constituted the alkyl group.