18618-02-5

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-6-METHYL-2-PHENYLQUINOLINE is used as a candidate for drug discovery and development, particularly in the creation of new medications and drugs. Its chemical structure makes it a potential candidate for antimicrobial or antimalarial agents, as well as other biological activities of interest for medicinal purposes.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 4-CHLORO-6-METHYL-2-PHENYLQUINOLINE is used as a potential antimicrobial agent, targeting various types of bacteria and contributing to the development of new treatments for bacterial infections.
Used in Antimalarial Applications:
4-CHLORO-6-METHYL-2-PHENYLQUINOLINE is also used as a potential antimalarial agent, with the aim of developing new medications to treat malaria and combat drug-resistant strains of the Plasmodium parasite.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 4-CHLORO-6-METHYL-2-PHENYLQUINOLINE serves as a subject for further research and development, exploring its potential biological activities and applications in the creation of novel therapeutic agents.

InChI:InChI=1/C16H12ClN/c1-11-7-8-15-13(9-11)14(17)10-16(18-15)12-5-3-2-4-6-12/h2-10H,1H3

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 106-49-0 p-toluidine 
• 102878-18-2 2,4-dichloro-6-methyl-quinoline 
• 98-80-6 phenylboronic acid 
• 1148-49-8 6-methyl-2-phenyl-quinolin-4-ol 

Downstream Products

• 132982-93-5 6-methyl-2-phenyl-[4]quinolylamine 

Relevant academic research and scientific papers

Tetranuclear Palladacycles of 3-Acetyl-7-methoxy-2 H-chromen-2-one Derived Schiff Bases: Efficient Catalysts for Suzuki-Miyaura Coupling in an Aqueous Medium

Tetranuclear organopalladium(II) complexes 1-3 and mononuclear complex 4 have been synthesized by the complexation of 3-acetyl-7-methoxy-2H-chromen-2-one derived Schiff bases with potassium tetrachloropalladate K2[PdCl4]. Structural confirmation for the complexes (1-3) has been achieved by single-crystal X-ray diffraction analysis. The ligands are found to bind with the palladium ion through its azomethine nitrogen, thiolate sulfur, and C4 carbon atom of the coumarin moiety subsequent to C-H activation. The monomeric nature of complex 4 was confirmed from its mass spectroscopic data. In complex 4, coordination occurred via the lactone oxygen, azomethine nitrogen, and thiolate sulfur atoms. Computational study has been used to determine the optimized molecular structures of the complexes. An explanation on the energies of their highest occupied and lowest unoccupied molecular orbital levels and their electronic spectra has also been provided on the basis of the theoretical calculations. A systematic study of the application of these complexes as catalysts in Suzuki-Miyaura coupling (SMC) has been done with different aryl halides and phenyl boronic acid in an aqueous medium. Optimization of the reaction indicated that complex 2 exhibits greater efficiency than other complexes. An appreciable yield of the coupled products was observed with the minimum use of catalyst (μmol), and the C-C coupling has been confirmed by GC/GC-MS. An interesting result of our catalyst is the coupling of four different chloroquinolines with phenyl boronic acid to afford the coupled products in good yields.

Quinoline derivatives as antitubercular/antibacterial agents

A number of quinoline derivatives of known antibacterial agents have been prepared and tested against the micro-organisms S. coli, S. paratyphi B, S. aureus and in particular against Mycobacterium tuberculosis H37-Rv. It has not been possibfe to establish correlation between antibacterial and antitubercular activities of these compounds. However, the antitubercular effect at MIC of 5 μg/mL against H37Rv shows that many modified compounds are more inhibitory than the parent agents such as 3-aminophenol, sulphamethoxazole, sulphaphenazole, sulphathiazole and monoacetyldapsone; among these the most effective are those with substituents such as 6-methyl, 6-chloro, 6-ethoxy-, or 8-methoxy functions in quinoline moiety.

4-Piperidino-2-phenylquinolines

Disclosed are compounds of the formula STR1 wherein: R1 and R2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R3 and R4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R3 and R4 cannot both be hydrogen. These compounds are useful as anticonvulsant or anxiolytic agents.