18619-18-6

Usage

Uses

Used in Pharmaceutical Industry:
O-chlorophenylthioacetate is used as a reagent in the synthesis of various pharmaceutical compounds. Its unique chemical properties make it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, o-chlorophenylthioacetate is utilized as a precursor in the production of various agrochemicals, such as pesticides and herbicides. Its role in the synthesis of these compounds contributes to the development of effective solutions for agricultural challenges.
Used in Organic Synthesis:
O-chlorophenylthioacetate is employed as a versatile reagent in organic synthesis, enabling the creation of a wide range of organic compounds. Its unique properties make it a valuable component in various chemical reactions, contributing to the advancement of organic chemistry.

InChI:InChI=1/C8H7ClO2S/c9-6-3-1-2-4-7(6)12-5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

Upstream product

• 6320-03-2 2-chlorothiphenol 
• 3926-62-3 sodium monochloroacetic acid 
• 94-56-4 2-aminophenylthioacetic acid 
• 79-11-8 chloroacetic acid 
• 68-11-1 mercaptoacetic acid 
• 95-51-2 o-chloroaniline 
• 694-80-4 2-bromo-1-chlorobenzene 
• 140-89-6 potassium ethyl xanthogenate 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 117696-98-7 (2-chloro-benzenesulfinyl)-acetic acid 
• 137583-58-5 ethyl 2-((2-chlorophenyl)thio)acetate 
• 31121-19-4 bis(2-chlorobenzene)disulfide 
• 6320-03-2 2-chlorothiphenol 
• 298-12-4 Glyoxilic acid 
• 6371-11-5 (E)-7,7'-dichloro-[2,2']bi[benzo[b]thiophenylidene]-3,3'-dione 
• 1370637-72-1 C₃₀H₂₆Cl₂N₂O₆S 

Relevant academic research and scientific papers

Discovery of Novel UDP- N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas aeruginosa LpxA with no activity against Escherichia coli LpxA. The biochemical potency of the series was optimized through an X-ray crystallography-supported medicinal chemistry program, resulting in compounds with nanomolar activity against P. aeruginosa LpxA (best half-maximal inhibitory concentration (IC50) 20 μM and MIC > 128 μg/mL). The mode of action of analogues was confirmed through genetic analyses. As expected, compounds were active against multidrug-resistant isolates. Further optimization of pharmacokinetics is needed before efficacy studies in mouse infection models can be attempted. To our knowledge, this is the first reported LpxA inhibitor series with selective activity against P. aeruginosa.

RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases

A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media

FMS-LIKE TYROSINE KINASE INHIBITORS

The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4

Background and Purpose: TRPM4 is a calcium-activated non-selective cation channel expressed in many tissues and implicated in several diseases, and has not yet been validated as a therapeutic target due to the lack of potent and selective inhibitors. We sought to discover a novel series of small-molecule inhibitors by combining in silico methods and cell-based screening assay, with sub-micromolar potency and improved selectivity from previously reported TRPM4 inhibitors. Experimental Approach: Here, we developed a high throughput screening compatible assay to record TRPM4-mediated Na+ influx in cells using a Na+-sensitive dye and used this assay to screen a small set of compounds selected by ligand-based virtual screening using previously known weakly active and non-selective TRPM4 inhibitors as seed molecules. Conventional electrophysiological methods were used to validate the potency and selectivity of the hit compounds in HEK293 cells overexpressing TRPM4 and in endogenously expressing prostate cancer cell line LNCaP. Chemical chaperone property of compound 5 was studied using Western blots and electrophysiology experiments. Key Results: A series of halogenated anthranilic amides were identified with TRPM4 inhibitory properties with sub-micromolar potency and adequate selectivity. We also showed for the first time that a naturally occurring variant of TRPM4, which displays loss-of-expression and function, is rescued by the most promising compound 5 identified in this study. Conclusions and Implications: The discovery of compound 5, a potent and selective inhibitor of TRPM4 with an additional chemical chaperone feature, revealed new opportunities for studying the role of TRPM4 in human diseases and developing clinical drug candidates.

ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.

KINETICS AND MECHANISM OF OXIDATION OF (ARYLTHIO)ACETIC ACIDS BY PYRIDINIUM HYDROBROMIDE PERBROMIDE

Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid.The reaction is first order with respect to PHPB.Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid.The effect of solvent composition indicates that the transition state is more polar than the reactants.The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures.The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett's substituent constants.The ρ value is -1.60 at 35 deg c.The rates of oxidation of ortho substituted compounds are correlated with Charton's triparametric equation.A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulphonium ion which hydrolyses in a subsequent fast step to the sulphoxide is proposed.

The Crystal Structure of Bis(2-chlorophenyl) Disulfide

The crystal structure of bis(2-chloropentyl) disulfide has been determined and refined to a residual of 0.035 for 1573 observed reflections.Crystals are monoclinic, space group P21/a with Z4 in a cell of dimensions a 7.724(1), b 22.360(7), c 7.