18619-21-1

Basic information

• Product Name: (2-Methoxy-phenylsulfanyl)-acetic acid
• Synonyms: (2-Methoxy-phenylsulfanyl)-acetic acid;2-((2-Methoxyphenyl)thio)acetic acid
• CAS NO: 18619-21-1
• Molecular Formula: C₉H₁₀O₃S
• Molecular Weight: 198.2389
• Mol File: 18619-21-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (2-Methoxy-phenylsulfanyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Methoxy-phenylsulfanyl)-acetic acid(18619-21-1)
• EPA Substance Registry System: (2-Methoxy-phenylsulfanyl)-acetic acid(18619-21-1)

Safety Data

• Hazardous Substances Data: 18619-21-1(Hazardous Substances Data)

Usage

General Description

(2-Methoxy-phenylsulfanyl)-acetic acid is a chemical compound with the molecular formula C9H10O3S. It is a derivative of acetic acid with a phenylsulfanyl group and a methoxy group attached to the benzene ring. (2-Methoxy-phenylsulfanyl)-acetic acid is commonly used in organic synthesis and pharmaceutical research due to its potential biological activities. It has been studied as a potential anti-inflammatory and anti-hypertensive agent, as well as a potential inhibitor of platelet aggregation. Additionally, (2-Methoxy-phenylsulfanyl)-acetic acid may also have applications in the development of new drugs for the treatment of various diseases and conditions.

Upstream product

• 7217-59-6 2-Methoxybenzenethiol 
• 3926-62-3 sodium monochloroacetic acid 
• 124-38-9 carbon dioxide 
• 2388-73-0 1-methoxy-2-(methylsulfanyl)benzene 
• 90-04-0 2-methoxy-phenylamine 
• 79-11-8 chloroacetic acid 

Downstream Products

• 7217-59-6 2-Methoxybenzenethiol 
• 298-12-4 Glyoxilic acid 

Relevant articles and documents

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(Alkylthio)methoxybenzenes have been metallated using two different metallating agents. The results show that sometimes superbases and butyllithium do not functionalize the same sites. Superbases monometallate the thiomethylic carbon of meta and para (methylthio)methoxybenzenes. The same substrates on the other hand are metallated by butyllithium in ortho to the methoxy group. One-step dimetallation performed with either superbases or butyllithium occurs at the thiomethylic carbon at the aryl carbon ortho to the methoxy group. Two consecutive one-pot monometallations of the para isomer (1c) with superbases occur at the thiomethylic carbon and at the annular carbon ortho to the methoxy group, in this order. A similar procedure with butyllithium metallates the two ortho positions to the methoxy group. Monometallation of (ethylthio) derivative (1d) yields, products substituted in ortho to the methoxy group using, either superbases or butyllithium. Dimetallation of this compound always substitutes the hydrogen ortho to the methoxy group and a thiomethylenic hydrogen.