18619-21-1Relevant academic research and scientific papers
RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases
Lee, Jiann-Fong,Chang, Ting-Yu,Liu, Zheng-Fang,Lee, Nian-Zhe,Yeh, Yen-Hsiu,Chen, Yi-Song,Chen, Tsung-Chih,Chou, Hao-Syun,Li, Tsai-Kun,Lee, Sung-Bau,Lin, Mei-Hsiang
, (2020/02/11)
A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media
FMS-LIKE TYROSINE KINASE INHIBITORS
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Page/Page column 25; 29; 59, (2020/03/31)
The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.
Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system
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, (2008/06/13)
Compounds of the formula: STR1 wherein R is a hydrogen atom or an OY group; R1 is a hydrogen atom or in OY' group; R2 is a hydrogen atom or an OY" group; provided that at lent one among R, R1 and R2 is hydrogen
KINETICS AND MECHANISM OF OXIDATION OF (ARYLTHIO)ACETIC ACIDS BY PYRIDINIUM HYDROBROMIDE PERBROMIDE
Karunakaran, K.,Elango, K. P.
, p. 429 - 434 (2007/10/02)
Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid.The reaction is first order with respect to PHPB.Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid.The effect of solvent composition indicates that the transition state is more polar than the reactants.The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures.The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett's substituent constants.The ρ value is -1.60 at 35 deg c.The rates of oxidation of ortho substituted compounds are correlated with Charton's triparametric equation.A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulphonium ion which hydrolyses in a subsequent fast step to the sulphoxide is proposed.
Metallation reactions. XX. Regioselective metallation of (alkylthio)methoxybenzenes by superbases versus organolithium compounds
Cabiddu,Fattuoni,Floris,Gelli,Melis
, p. 4965 - 4974 (2007/10/02)
(Alkylthio)methoxybenzenes have been metallated using two different metallating agents. The results show that sometimes superbases and butyllithium do not functionalize the same sites. Superbases monometallate the thiomethylic carbon of meta and para (methylthio)methoxybenzenes. The same substrates on the other hand are metallated by butyllithium in ortho to the methoxy group. One-step dimetallation performed with either superbases or butyllithium occurs at the thiomethylic carbon at the aryl carbon ortho to the methoxy group. Two consecutive one-pot monometallations of the para isomer (1c) with superbases occur at the thiomethylic carbon and at the annular carbon ortho to the methoxy group, in this order. A similar procedure with butyllithium metallates the two ortho positions to the methoxy group. Monometallation of (ethylthio) derivative (1d) yields, products substituted in ortho to the methoxy group using, either superbases or butyllithium. Dimetallation of this compound always substitutes the hydrogen ortho to the methoxy group and a thiomethylenic hydrogen.
