186406-63-3

Upstream product

• 135840-16-3 (2S,4S,5S)-4-hydroxymethyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 917-54-4 methyllithium 
• 186406-53-1 (2S,4S,5S)-4-formyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 

Downstream Products

• 186406-54-2 (2S,4S,5S)-4-acetyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 
• 186406-69-9 ((E)-(2R,6S,8R,9R,10S,12R)-2-Allyl-9,13-bis-benzyloxy-8,10-dimethoxy-4,6,12-trimethyl-tridec-3-enyloxy)-tert-butyl-dimethyl-silane 
• 135840-32-3 (S)-1-[2-{(2R,3R,5S,6R)-6-[(E)-(1S,3S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methoxy-3,5-dimethyl-deca-5,9-dienyl]-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl}-2-(4-methoxy-benzyloxy)-acetyl]-piperidine-2-carboxylic acid methyl ester 
• 186406-68-8 (E)-(2R,4S,5R,6R,8S,12R)-1,5-Bis-benzyloxy-12-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-2,8,10-trimethyl-pentadeca-10,14-dien-6-ol 
• 186406-67-7 (E)-(2R,4S,5S,8S,12R)-7-Benzenesulfonyl-1,5-bis-benzyloxy-12-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-2,8,10-trimethyl-pentadeca-10,14-dien-6-one 
• 186406-66-6 (E)-(2R,4S,5R,8S,12R)-7-Benzenesulfonyl-1,5-bis-benzyloxy-12-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-2,8,10-trimethyl-pentadeca-10,14-dien-6-ol 
• 135840-28-7 (2R,4S,5S,8S,10E,12R)-1,5-dibenzyloxy-12-(tert-butyldimethylsilyl)oxymethyl-4-methoxy-2,8,10-trimethyl-10,14-pentadecadien-6-one 
• 186406-60-0 (4R,5E,8S,10S,11R,12S,14R)-11,15-dibenzyloxy-4-(tert-butyldimethylsilyl)oxymethyl-10,12-dimethoxy-6,8,14-trimethyl-1,5-pentadecadiene 
• 135840-29-8 (2R,4S,5R,6S,8S,10E,12R)-1,5-dibenzyloxy-12-(tert-butyldimethylsilyl)oxymethyl-4-methoxy-2,8,10-trimethyl-10,14-pentadecadien-6-ol 
• 135840-21-0 (4R,5E,8S)-4-(tert-butyldimethylsilyl)oxymethyl-6,8-dimethyl-9-(phenylsulfonyl)-1,5-nonadiene 
• 135840-17-4 (2S,4S,5S)-4-isopropenyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 

Relevant academic research and scientific papers

Stereocontrolled synthesis of C10-C22 fragment of the immunosuppressant FK 506. An occurrence of complementary stereoselectivity in the C15 ketone reduction

The stereoselective syntheses of the C10-C22 fragment 2a and its C15-epimer 2b of the immunosuppressant FK 506 1 have been carried out through convergent coupling of the sulfone 3, which could be constructed by highly stereocontrolled ester-enolate Claise

A Synthesis of C1-C22 Fragment of the Immunosuppressant FK 506. Stereoselective Construction of (E)-Trisubstituted Double Bond (C19-C20) via Ester-enolate Claisen Rearrangement

An ene-ester 5 prepared from L-malic acid was subjected to the ester-enolate Claisen rearrangement under Ireland's condition to give stereoselectively C16-C22 fragment 11 containing (E)-trisubstituted double bond which was further advanced to C1-C22 fragm