186406-60-0

Upstream product

• 135840-29-8 (2R,4S,5R,6S,8S,10E,12R)-1,5-dibenzyloxy-12-(tert-butyldimethylsilyl)oxymethyl-4-methoxy-2,8,10-trimethyl-10,14-pentadecadien-6-ol 
• 74-88-4 methyl iodide 
• 17618-04-1 2,5-di-O-benzyl-D-mannitol 
• 186406-55-3 (2S,3S)-4-methyl-2-(2-propenyl)-4-pentene-1,3-diol 
• 186406-56-4 (3S,4S)-4-(tert-butyldimethylsilyl)oxymethyl-2-methyl-1,6-heptadien-3-ol 
• 186406-63-3 1-((2S,4S,5S)-5-Allyl-2-phenyl-[1,3]dioxan-4-yl)-ethanol 
• 186406-64-4 ((E)-(2R,6S)-2-Allyl-7-iodo-4,6-dimethyl-hept-3-enyloxy)-tert-butyl-dimethyl-silane 
• 135840-17-4 (2S,4S,5S)-4-isopropenyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 
• 135840-20-9 (2S,4E,6R)-6-(tert-butyldimethylsilyl)oxymethyl-2,4-dimethyl-4,8-nonadien-1-ol 
• 186406-54-2 (2S,4S,5S)-4-acetyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 
• 186406-53-1 (2S,4S,5S)-4-formyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 
• 135840-16-3 (2S,4S,5S)-4-hydroxymethyl-2-phenyl-5-(2-propenyl)-1,3-dioxacyclohexane 
• 135840-18-5 (1S,2S)-2-(tert-butyldimethylsilyl)oxymethyl-1-isopropenyl-4-pentenyl propanoate 
• 135840-19-6 (2S,4E,6R)-6-(tert-butyldimethylsilyl)oxymethyl-2,4-dimethyl-4,8-nonadienoic acid 

Downstream Products

• 135840-32-3 (S)-1-[2-{(2R,3R,5S,6R)-6-[(E)-(1S,3S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methoxy-3,5-dimethyl-deca-5,9-dienyl]-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl}-2-(4-methoxy-benzyloxy)-acetyl]-piperidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Stereocontrolled synthesis of C10-C22 fragment of the immunosuppressant FK 506. An occurrence of complementary stereoselectivity in the C15 ketone reduction

The stereoselective syntheses of the C10-C22 fragment 2a and its C15-epimer 2b of the immunosuppressant FK 506 1 have been carried out through convergent coupling of the sulfone 3, which could be constructed by highly stereocontrolled ester-enolate Claise

A Synthesis of C1-C22 Fragment of the Immunosuppressant FK 506. Stereoselective Construction of (E)-Trisubstituted Double Bond (C19-C20) via Ester-enolate Claisen Rearrangement

An ene-ester 5 prepared from L-malic acid was subjected to the ester-enolate Claisen rearrangement under Ireland's condition to give stereoselectively C16-C22 fragment 11 containing (E)-trisubstituted double bond which was further advanced to C1-C22 fragm