18651-15-5Relevant articles and documents
Synthesis of novel substituted pyrano annulated flavones
Jayaprakash Rao,Thirupathi,Prasad Rao, Ch.,Hemasri
, p. 1126 - 1131 (2016/07/06)
A simple and efficient one pot method has been developed for the synthesis of some new functionalized pyrano fused flavone derivatives, alkyl 4,8-dioxo-2-phenyl-4,8-dihydropyrano[2,3-f]chromene-10-carboxylates and dialkyl 4-oxo-2-phenyl-4,8-dihydropyrano[2,3-f]chromene-8,9-dicarboxylates, from 7-hydroxy flavones and 7-hydroxy 8-formyl flavones using dialkylacetalynedicarboxylates in the presence of triphenyl phosphine. The structures of all synthesized compounds were elucidated by FT-IR, 1H and 13C NMR and Mass spectral analysis.
Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor
Ungwitayatorn, Jiraporn,Wiwat, Chanpen,Samee, Weerasak,Nunthanavanit, Patcharawee,Phosrithong, Narumol
experimental part, p. 152 - 161 (2011/10/03)
Novel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the preliminary screening. The most potent compound, 7,8-dihydroxy-2-(3′-trifluoromethyl phenyl)-3-(3″- trifluoromethylbenzoyl)chromone (32), showed IC50 = 0.34 μM. The molecular docking study supported results from experimental activity testing and also provided structure-activity relationship of this series.
A New Synthesis of 9-Methylfuroflavones
Prasunamba, P. L.,Srimannarayana, G.
, p. 71 - 72 (2007/10/02)
9-Methylfuroflavones (III) have been synthesised by thermal Claisen rearrangement of 7-propargyloxy flavones (II).