858258-32-9

Basic information

• Product Name: 7-benzoyloxy-3-methyl-2-phenyl-chromen-4-one
• Synonyms: 7-benzoyloxy-3-methyl-2-phenyl-chromen-4-one
• CAS NO: 858258-32-9
• Molecular Weight: 356.378
• Mol File: 858258-32-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-benzoyloxy-3-methyl-2-phenyl-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzoyloxy-3-methyl-2-phenyl-chromen-4-one(858258-32-9)
• EPA Substance Registry System: 7-benzoyloxy-3-methyl-2-phenyl-chromen-4-one(858258-32-9)

Safety Data

• Hazardous Substances Data: 858258-32-9(Hazardous Substances Data)

Upstream product

• 5792-36-9 2',4'-dihydroxypropiophenone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 93875-99-1 7-Acetyloxy-3-methylflavone 
• 18651-15-5 7-hydroxy-3-methylflavone 

Relevant articles and documents

Synthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor

Novel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the preliminary screening. The most potent compound, 7,8-dihydroxy-2-(3′-trifluoromethyl phenyl)-3-(3″- trifluoromethylbenzoyl)chromone (32), showed IC50 = 0.34 μM. The molecular docking study supported results from experimental activity testing and also provided structure-activity relationship of this series.