186590-01-2

Usage

Uses

Used in Pharmaceutical Research:
4-fluoro-2-hydroxybenzonitrile is used as a research compound for studying the substituent effect on fluorobenzene derivatives. Specifically, it is employed to investigate the impact of different substituents on the cytochrome P450-catalyzed hydroxylation at the adjacent ortho aromatic carbon center. This research is crucial for understanding the metabolism and biotransformation of fluorinated compounds, which can lead to the development of more effective and safer pharmaceuticals.
Used in Chemical Synthesis:
Due to its unique structure, 4-fluoro-2-hydroxybenzonitrile can be used as a building block or intermediate in the synthesis of various organic compounds. Its presence of a nitrile group makes it a versatile starting material for the preparation of amines, amides, and other nitrogen-containing compounds. Additionally, the hydroxyl and fluorine substituents can be utilized for further functionalization and modification of the molecule, expanding its potential applications in the chemical industry.
Used in Material Science:
The distinct electronic and steric properties of 4-fluoro-2-hydroxybenzonitrile can make it a valuable component in the development of new materials with specific properties. For instance, it can be incorporated into polymers to create materials with tailored characteristics, such as improved thermal stability, enhanced solubility, or altered optical properties. Furthermore, its potential use in the synthesis of novel coordination compounds or metal-organic frameworks could lead to advances in areas like catalysis, gas storage, or sensing.

Upstream product

• 372-20-3 3-fluorophenol 
• 191014-55-8 2-methoxy-4-fluorobenzonitrile 

Downstream Products

• 870562-91-7 4-fluoro-2-(2-morpholino-2-oxoethoxy)benzonitrile 
• 1255870-63-3 4-bromo-2-ethoxybenzonitrile 
• 1323276-31-8 (S)-4-(3-(2-(3-(2-cyano-5-fluorophenoxy)-2-hydroxypropylamino)ethyl)ureido)benzoic acid 
• 1323276-82-9 (S)-4-fluoro-2-(oxiran-2-ylmethoxy)benzonitrile 
• 870562-95-1 2-hydroxy-4-fluoro-benzylamine hydrochloride 
• 933772-76-0 2-difluoromethoxy-4-fluoro-benzonitrile 
• 870562-93-9 dimethyl-carbamic acid 2-cyano-5-fluoro-phenyl ester 

Relevant academic research and scientific papers

Lewis acid-promoted site-selective cyanation of phenols

An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.

Phenyl-1,2,4-Oxadiazolone Derivatives, Processes For Their Preparation and Methods For Their Use as Pharmaceuticals

The inventive compounds of the present invention are comprised of phenyl and pyridinyl-1,2,4-oxadiazolone derivatives and their physiologically acceptable salts and functional derivatives that are shown to provide peroxisome proliferator activator recepto

HIV integrase inhibitors

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS

The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS

The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity. What is described are compounds of the formula (I) in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.

NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE

[From equivalent EP1710233A1] The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, arylalkenyl, aryloxy-lower alkyl, heteroaryl, heteroaryl-lower alkyl, etc; R3, R4, R5 and R6 are each hydrogen, halogen, cyano, lower alkyl, halo-lower alkyl, lower alkoxy, hydroxy, aryl, etc; provided that at least one of R3, R4, R5 and R6 is other than hydrogen. Compound (I) of the present invention shows a potent adenosine A2A receptor antagonistic activity, and are useful for treating or preventing a disease mediated by adenosine A2A receptors such as motor function disorders, depression, anxiety disorders, cognitive function disorders, cerebral ischemia disorders, restless legs syndrome and the like.

Bicyclic heterocycles as HIV integrase inhibitors

The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.