131036-39-0

Basic information

• Product Name: 3-Bromo-5-Chloro-2-Picoline
• Synonyms: 3-Bromo-5-Chloro-2-Picoline;3-BroMo-5-chloro-2-Methylpyridine
• CAS NO: 131036-39-0
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.4676
• Mol File: 131036-39-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Bromo-5-Chloro-2-Picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-Chloro-2-Picoline(131036-39-0)
• EPA Substance Registry System: 3-Bromo-5-Chloro-2-Picoline(131036-39-0)

Safety Data

• Hazardous Substances Data: 131036-39-0(Hazardous Substances Data)

Usage

Description

3-Bromo-5-Chloro-2-Picoline, also known as 3-Bromo-5-Chloro-2-Picoline, is an organic compound with the molecular formula C6H4BrClN. It is a derivative of picoline, a heterocyclic compound with a nitrogen atom in the ring structure. 3-Bromo-5-Chloro-2-Picoline is characterized by the presence of a bromine atom at the 3rd position and a chlorine atom at the 5th position on the pyridine ring. It is known for its potential applications in various industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
3-Bromo-5-Chloro-2-Picoline is used as a reagent for the development of picomolar inhibitors of HIV reverse transcriptase. It is particularly effective in the creation of inhibitors featuring bicyclic replacement of the cyanovinylphenyl substructure. This application is significant in the fight against HIV/AIDS, as it aids in the development of potent and specific inhibitors that can effectively target the virus and limit its replication.

Upstream product

• 186593-42-0 3-bromo-2-methyl-5-nitropyridine 
• 186593-43-1 5-amino-3-bromo-2-methylpyridine 
• 75-16-1 methylmagnesium bromide 
• 137628-17-2 2,3-dibromo-5-chloro-pyridine 
• 13061-96-6 dihydroxy-methyl-borane 

Downstream Products

• 1621225-24-8 5-chloro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1227588-49-9 3-bromo-5-chloropyridine-2-carbaldehyde 

Relevant articles and documents

MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS

The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Compounds and their use as BACE Inhibitors

The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.