18693-11-3

Basic information

• Product Name: 4-hydroxy-3-(phenylsulfanyl)-2(1H)-quinolinone
• Synonyms: 4-hydroxy-3-(phenylsulfanyl)-2(1H)-quinolinone
• CAS NO: 18693-11-3
• Molecular Formula: C₁₅H₁₁NO₂S
• Molecular Weight: 269.31834
• Mol File: 18693-11-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 405°C at 760 mmHg
• Flash Point: 198.7°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 2.76E-07mmHg at 25°C
• Refractive Index: 1.735
• CAS DataBase Reference: 4-hydroxy-3-(phenylsulfanyl)-2(1H)-quinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-(phenylsulfanyl)-2(1H)-quinolinone(18693-11-3)
• EPA Substance Registry System: 4-hydroxy-3-(phenylsulfanyl)-2(1H)-quinolinone(18693-11-3)

Safety Data

• Hazardous Substances Data: 18693-11-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H11NO2S/c17-13-11-8-4-5-9-12(11)16-15(18)14(13)19-10-6-2-1-3-7-10/h1-9H,(H2,16,17,18)

Upstream product

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Downstream Products

• 204642-78-4 2,4-dichloro-3-phenylsulfanyl-quinoline 

Relevant articles and documents

Novel Method for Preparing 4-hydroxy-3-sulfanylcoumarin Derivatives or 4-hydroxy-3-sulfanylquinoline Derivatives and Their Compounds Made Thereby, and Its Use

The present invention relates to 4-hydroxy-3-sulfanylcoumarin derivatives represented by chemical formula 1, 4-hydroxy-3-sulfanylquinolinone derivatives represented by chemical formula 2, novel preparation methods thereof, and uses thereof. According to the present invention, the preparation methods can reduce the preparation cost by utilizing inexpensive catalysts, and at the same time, can yield desired products with high yield. In the chemical formula 1, R_1 to R_4 are as described in the present invention. In the chemical formula 2, R_5 to R_7 are as described in the present invention.COPYRIGHT KIPO 2018

Conformational analysis of tandospirone in aqueous solution: Lead evolution of potent dopamine D4 receptor ligands

The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.

Synthesis of 4-Hydroxy-2(1H)-pyridones from Azomethines and Substituted Dialkylmalonates

The reaction of azomethines 4 with substituted dialkyl malonates 5 leads to the formation of 3-substituted 4-hydroxy-2(1H)-pyridones 6 in moderate yields. The azomethines 4 are prepared via arylaminopropionitriles 3 or in the conventional way by acid catalyzed condensation of ketones 1 with anilines 2. Chlorination of pyridones 6 with sulfuryl chloride leads to compounds 8-10.