18693-11-3Relevant academic research and scientific papers
Novel Method for Preparing 4-hydroxy-3-sulfanylcoumarin Derivatives or 4-hydroxy-3-sulfanylquinoline Derivatives and Their Compounds Made Thereby, and Its Use
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Paragraph 0109; 0110; 0153; 0154, (2018/10/16)
The present invention relates to 4-hydroxy-3-sulfanylcoumarin derivatives represented by chemical formula 1, 4-hydroxy-3-sulfanylquinolinone derivatives represented by chemical formula 2, novel preparation methods thereof, and uses thereof. According to the present invention, the preparation methods can reduce the preparation cost by utilizing inexpensive catalysts, and at the same time, can yield desired products with high yield. In the chemical formula 1, R_1 to R_4 are as described in the present invention. In the chemical formula 2, R_5 to R_7 are as described in the present invention.COPYRIGHT KIPO 2018
Copper(I) Bromide-Dimethyl Sulfide-Catalyzed Direct Sulfanylation of 4-Hydroxycoumarins and 4-Hydroxyquinolinones with Arylsulfonylhydrazides and Selective Fluorescence Switch- On Sensing of Cadmium(II) Ion in Water
Paul, Sanjay,Shrestha, Rajeev,Edison,Lee, Yong Rok,Kim, Sung Hong
supporting information, p. 3050 - 3056 (2016/10/09)
An efficient protocol for the direct sulfanylation of various 4-hydroxycoumarins and 4-hydroxyquinolinones in good yield with arylsulfonylhydrazides as sulfanylating agents was developed via copper(I) bromide?dimethyl sulfide-catalyzed S–O, S–N bond cleavage and C–S cross-coupling reactions. A highly selective fluorescence turning-on sensing of cadmium(II) ions in water using the synthesized 3-sulfanyl-4-hydroxycoumarin derivative was also investigated. (Figure presented.).
Conformational analysis of tandospirone in aqueous solution: Lead evolution of potent dopamine D4 receptor ligands
Nishimura, Tamiki,Igarashi, Jun-etsu,Sunagawa, Makoto
, p. 1141 - 1144 (2007/10/03)
The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.
Solution-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones
Kulkarni, Bheemashankar A.,Ganesan
, p. 785 - 786 (2007/10/03)
Ion-exchange resins catalyse an intramolecular Claisen-type condensation leading to the title compounds, and also serve to purify the products.
Synthesis of 4-Hydroxy-2(1H)-pyridones from Azomethines and Substituted Dialkylmalonates
Kafka,Kappe
, p. 1019 - 1031 (2007/10/03)
The reaction of azomethines 4 with substituted dialkyl malonates 5 leads to the formation of 3-substituted 4-hydroxy-2(1H)-pyridones 6 in moderate yields. The azomethines 4 are prepared via arylaminopropionitriles 3 or in the conventional way by acid catalyzed condensation of ketones 1 with anilines 2. Chlorination of pyridones 6 with sulfuryl chloride leads to compounds 8-10.
Ylides of Heterocycles, VIII. Reactions of Iodonium-Ylides with Acids
Pongratz, Erik,Kappe, Thomas
, p. 231 - 242 (2007/10/02)
The reaction of various organic and inorganic acids (HX) with iodonium ylides 2 leads to nucleophilic substitution of the iodobenzene substituent by the anion X(-) to yield the heterocycles 5.Some of them are hydrolyzed to the hydroxy compounds 3 or reduced to the starting compounds 1 under the reaction conditions.Reaction of the iodonium ylide 2b with monomethyl sulfate gives the salt 9, which with bases undergoes nucleophilic substitution to compounds 8 and 10-12, respectively, or is converted to 2b again. - Keywords: 3-Acetoxy-4-hydroxy-2-quinolones; 2-Oxoquinoline-4-olates; 3-Substituted 4-hydroxy-2-quinolones
