18700-01-1

Basic information

• Product Name: cis-2,6-diphenyl-trans-3,5,N-trimethylpiperidin-4-one
• Synonyms: cis-2,6-diphenyl-trans-3,5,N-trimethylpiperidin-4-one
• CAS NO: 18700-01-1
• Molecular Weight: 293.409
• Mol File: 18700-01-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: cis-2,6-diphenyl-trans-3,5,N-trimethylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2,6-diphenyl-trans-3,5,N-trimethylpiperidin-4-one(18700-01-1)
• EPA Substance Registry System: cis-2,6-diphenyl-trans-3,5,N-trimethylpiperidin-4-one(18700-01-1)

Safety Data

• Hazardous Substances Data: 18700-01-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 96-22-0 pentan-3-one 
• 74-89-5 methylamine 
• 87961-27-1 C₂₀H₂₄⁽²⁾HNO 
• 87961-23-7 C₂₀H₂₄⁽²⁾HNO 
• 87961-23-7 C₂₀H₂₄⁽²⁾HNO 
• 5707-11-9 r-2,c-6-diphenyl-t-3,t-5-dimethylpiperidin-4-one 
• 74-88-4 methyl iodide 
• 37418-39-6 1,3,5-trimethyl-2,6-diphenylpiperidin-4-one oxime 
• 74-86-2 acetylene 
• 1201804-41-2 3e,5e-dimethyl-2e,6e-diphenyl-4-piperidone 
• 5707-11-9 3,5-dimethyl-2,6-diphenylpiperidin-4-one 
• 43051-68-9 t-2,t-6-diphenyl-c-3,c-5,N-trimethylpiperidin-r-4-ol 
• 43051-69-0 c-2,c-6-diphenyl-t-3,t-5,N-trimethylpiperidin-r-4-ol 

Downstream Products

• 87961-27-1 C₂₀H₂₄⁽²⁾HNO 
• 87961-23-7 C₂₀H₂₄⁽²⁾HNO 
• 37418-39-6 (2R,3S,5R,6S)-1,3,5-Trimethyl-2,6-diphenyl-piperidin-4-one oxime 
• 43051-69-0 c-2,c-6-diphenyl-t-3,t-5,N-trimethylpiperidin-r-4-ol 
• 43051-68-9 t-2,t-6-diphenyl-c-3,c-5,N-trimethylpiperidin-r-4-ol 
• 37418-39-6 1,3,5-trimethyl-2,6-diphenylpiperidin-4-one oxime 
• 95-14-7 1,2,3-Benzotriazole 
• 20547-23-3 1,3c,5c-trimethyl-2t,4,6t-triphenyl-piperidin-4r-ol 

Relevant articles and documents

Oxidative deoximation of N-methyl-2,6-diphenyl piperidin-4-one oxime and its 3-alkyl derivatives by acid dichromate

Kinetics of oxidation of N-methyl-2,6-diphenyl piperidin-4-one and its 3-alkyl substituted derivatives by acid dichromate has been studied in aqueous acetic acid medium. The oxidation is first order with respect to [oxidant] and [substrate]. The reactions are acid catalyzed. Ionic strength has no appreciable effect on the reaction rate. The reaction rate decreases with decrease in the dielectric strength of the medium indicating a polar mechanism. The reactions followed at four different temperatures and the activation parameters computed. Based on the results obtained a suitable mechanism is proposed. The reactivity sequence is found to be 1,3,5-trimethyl PPO > 1-methyl PPO > 1,3-dimethyl PPO > 1-methyl-3-ethyl PPO > 1-methyl-3-isopropyl PPO.

A piperidinium triflate catalyzed Biginelli reaction

A piperidinium triflate, 1,1,3,5-tetramethyl-4-oxo-2,6-diphenylpiperidinium triflate, in acetonitrile efficiently catalyzes one synthetic operational construction of biopertinent hydropyrimidines from respective aldehyde, β-dicarbonyl, and urea/thiourea building blocks.

Heterocyclization of oximes of 3,5-dimethyl(1,3,5-trimethyl)-2,6- diphenylpiperid-4-ones and N-benzylpyrrolid-3-ones with acetylene in a superbasic medium

It has been established that on heterocyclization of 3,5-dimethyl-2,6- diphenylpiperid-4-one oxime with acetylene in a superbasic medium migration of the 3a-CH3 group to the anionic nitrogen atom occurs, leading to the formation of 5,7-dimethyl-4,6-diphenyl-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridine. The formation of the N-anion causes aromatization of the tetrahydropyridine ring. Tetrahydropyrrolo-[1,2-c]pyrimidines are formed in the Trofimov reaction as a result of decomposition of the intermediate 3H-pyrrole in a retro-Mannich reaction.