18712-15-7

Usage

Uses

Used in Lifespan-Altering Applications:
3-Ethoxy 1,2-benzisothiazole 1,1-dioxide is used as a lifespan-altering compound for altering the lifespan of eukaryotic organisms. It is employed in methods that involve the use of such compounds to study and potentially extend or modify the lifespan of various eukaryotic organisms, including but not limited to yeast, worms, flies, and potentially mammals.
Additionally, 3-Ethoxy 1,2-benzisothiazole 1,1-dioxide is utilized in screening processes to identify and characterize other compounds with similar or enhanced lifespan-altering properties. This can contribute to the development of new therapeutic agents or interventions aimed at promoting healthspan and extending the lifespan of organisms.

Upstream product

• 64-17-5 ethanol 
• 567-19-1 3-chloro-1,2-benzisothiazole 1,1-dioxide 
• 81-07-2 saccharin 
• 1569262-64-1 ethyl N-tert-butyl-4-nitrobenzenesulfonimidate 
• 75-03-6 ethyl iodide 
• 132636-65-8 3-(4-nitro-phenoxy)-benz[d]isothiazole-1,1-dioxide 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 61766-85-6 (5-ethoxy-4-methyl-1,1-dioxo-1H-1λ⁶-benzo[f][1,2]thiazepin-3-yl)-diethyl-amine 
• 124401-04-3 3-(2-(Trifluoromethyl)phenyl)-1,2-benzisothiazole 1,1-Dioxide 
• 124401-05-4 3-(4-(Trifluoromethyl)phenyl)-1,2-benzisothiazole 1,1-Dioxide 
• 131759-32-5 (+)-3--1,2-benzisothiazole 1,1-dioxide 
• 53440-57-6 3-phenylbenzo[d]isothiazole-1,1-dioxide 
• 124401-03-2 3-(2,6-Dimethoxyphenyl)-1,2-benzisothiazole 1,1-Dioxide 
• 81-07-2 saccharin 
• 124401-11-2 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide 
• 124401-15-6 3-(4-(Trifluoromethyl)phenyl)-1,2-benzisothiazole 1,1-dioxide oxide 
• 124401-14-5 3-(2-(Trifluoromethyl)phenyl)-1,2-benzisothiazole 1,1-dioxide oxide 
• 124401-13-4 3-(2,6-Dimethoxyphenyl)-1,2-benzisothiazole 1,1-dioxide oxide 
• 124401-16-7 3-(Pentafluorophenyl)-1,2-benzisothiazole 1,1-dioxide oxide 
• 38938-55-5 3-(4-methoxyphenyl)-1,2-benzisothiazole 1,1-dioxide 
• 1093168-43-4 3-(3-methoxyphenyl)-1,2-benzisothiazole 1,1-dioxide 

Relevant academic research and scientific papers

SNAAP sulfonimidate alkylating agent for acids, alcohols, and phenols 1

Stable, crystalline ethyl N-tert-butyl-4-nitrobenzenesulfonimidate has been prepared in high yield by direct O-ethylation of N-tert-butyl-4- nitrobenzenesulfonamide with iodoethane and silver(I) oxide in dichloromethane. This sulfonimidate directly ethylates various acids to esters; the stronger the acid, the faster it alkylates and in higher yield. It readily ethylates alcohols and phenols to ethers at room temperature in the presence of tetrafluoroboric acid catalyst without molecular rearrangements or racemization. We have defined these reactions as SNAAP alkylations: [substitution, nucleophilic of acids, alcohols and phenols]. The hard sulfonimidate alkylating agent is chemoselective, preferring oxygen > nitrogen > sulfur. The sulfonamide byproduct of alkylation is readily recycled to the sulfonimidate. Georg Thieme Verlag Stuttgart . New York.

Enantioselective Pd-catalyzed hydrogenation of enesulfonamides

Asymmetric hydrogenation of cyclic enesulfonamides affords chiral cyclic sulfonamides using Pd(OCOCF3)2/diphosphine complexes as catalysts with up to 98% ee.

Electronic effects on C-O-C ether bonds in 3-aryloxy derivatives of benzisothiazole 1,1-dioxides: rapid ethanolysis of 3-(4-nitrophenoxy)-1,2-benzisothiazole 1,1-dioxide, (1), to give 3-ethoxy-1,2-benzisothiazole 1,1-dioxide, (2)

The bond lengths in the central C-O-C ether link-age of title compound (1), C13H8N2O5S, are comparable with those found in earlier work on similar compounds. However, (1) was found to undergo very easy solvolysi

Sulfur Oxidation Mediated by Imine Derivatives

A number of oxime and benzothiazoline derivatives have been prepared and examined as mediators of sulfur oxidation by hydrogen peroxide as oxidant in the presence of base.In all cases, sulfoxidation was observed in the presence of the mediators, whereas negligible reaction occured in the absence of mediators.Carbodiimides were also examined as mediators; they proved to be highly reactive, providing predominant oxidation directly to sulfone.

Metal-assisted reactions. Part 26.1 Catalytic reactivity and ether bond lengths in aryloxytetrazoles and aryloxypseudosaccharins

X-Ray structure determinations on a variety of aryloxytetrazoles 1 and aryloxypseudosaccharins 4 have shown that the central C-O-C ether linkage is remarkable in having one very long C-O bond and one very short one. The central C-O-C bond angle is close t

Substituted 2,3-dihydro-1,2,4-triazolo [4,3-b][1,2]benzisothiazol-3-amine, 5,5, dioxides

2,3-Dihydro-1,2,4-triazolo[4,3-b][1,2]benzisothiazol-3-amine, 5,5-dioxides having the formula STR1 and salts thereof are new compounds which are useful as anti-inflammatory agents.