187278-01-9

Basic information

• Product Name: 5-[(4-Bromophenylamino)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione ,98%
• Synonyms: 5-[(4-Bromophenylamino)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione ,98%;5-((4-Bromophenylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione;5-[(4-bromoanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 187278-01-9
• Molecular Formula: C₁₃H₁₂BrNO₄
• Molecular Weight: 326.14268
• Mol File: 187278-01-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-[(4-Bromophenylamino)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione ,98%(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(4-Bromophenylamino)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione ,98%(187278-01-9)
• EPA Substance Registry System: 5-[(4-Bromophenylamino)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione ,98%(187278-01-9)

Safety Data

• Statements: 22-38
• Safety Statements: 36/37/39-45
• Hazardous Substances Data: 187278-01-9(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

Upstream product

• 15568-86-2 5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 106-40-1 4-bromo-aniline 
• 2033-24-1 cycl-isopropylidene malonate 
• 122-51-0 orthoformic acid triethyl ester 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 1551455-21-0 N-(2-methoxy-5-(4-((trimethylsilyl)ethynyl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide 
• 1551455-28-7 2-fluoro-N-(2-methoxy-5-(4-((trimethylsilyl)ethynyl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide 
• 145369-94-4 6-bromoquinolin-4-ol 
• 65340-70-7 6-bromo-4-chloroquinoline 
• 1551453-19-0 2,4-difluoro-N-(5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 
• 1551454-59-1 2,4-difluoro-N-(2-methoxy-5-(4-((trimethylsilyl)ethynyl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide 
• 1551453-47-4 N-(5-(4-ethynylquinolin-6-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide 
• 1551453-50-9 N-(5-(4-((1H-pyrazol-4-yl)ethynyl)quinolin-6-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide 
• 1551453-54-3 2,4-difluoro-N-(2-methoxy-5-(4-((1-methyl-1H-pyrazol-4-yl)ethynyl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide 
• 1551453-57-6 N-(5-(4-cyano-quinolin-6-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide 
• 1551453-75-8 N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide 
• 853908-50-6 6-bromo-3-nitroquinolin-4-ol 
• 723281-72-9 6-bromo-4-chloro-3-nitroquinoline 

Relevant articles and documents

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Sulfonylurea compound as well as preparation method and application thereof

The invention discloses a sulfonylurea compound, geometrical isomers or pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, and a preparation method thereof. The sulfonylurea compound, the pharmaceutically acceptable salts, hydrates or solvates serving as active ingredients are mixed with pharmaceutically acceptable carriers or excipients to prepare compositions and preparedinto clinically acceptable dosage forms. The invention further discloses application of the compounds in preparation of medicines for treating and/or preventing proliferative diseases, application inpreparation of medicines for treating and/or preventing cancers, and application in preparation of medicines for treating and/or prostatic cancer, lung cancer and breast cancer.

6-bromo-4-chloroquinoline preparation method

The invention discloses a 6-bromo-4-chloroquinoline preparation method. 4-bromaniline, ethyl propiolate, phosphorus trichloride and the like are used as raw materials to obtain a target product 6-bromo-4-chloroquinoline through three-step reaction. The 6-bromo-4-chloroquinoline preparation method is convenient and simple in operation and environment friendly, the comprehensive yield is 70% or above and remarkably increased as compared with existing yield which is 26-42%, existing medicine production cost is sharply reduced, and the 6-bromo-4-chloroquinoline preparation method is suitable for industrial mass production.