18773-95-0

Basic information

• Product Name: 2-Acetylbenzimidazole
• Synonyms: 1H-Benzimidazole,1-acetyl-;1H-Benzimidazole, 1-acetyl- (9CI);2-Acetyl-1H-benzimidazole;2-Acetylbenzimidazole;1-(1H-1,3-benzodiazol-2-yl)ethan-1-one
• CAS NO: 18773-95-0
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Product Categories: ACETYLGROUP;BENZIMIDAZOLE;Imidazol&Benzimidazole;Imidaxoles
• Mol File: 18773-95-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 347.402 °C at 760 mmHg
• Flash Point: 167.988 °C
• Appearance: /
• Density: 1.265 g/cm³
• CAS DataBase Reference: 2-Acetylbenzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetylbenzimidazole(18773-95-0)
• EPA Substance Registry System: 2-Acetylbenzimidazole(18773-95-0)

Safety Data

• Hazardous Substances Data: 18773-95-0(Hazardous Substances Data)

Usage

General Description

2-Acetylbenzimidazole, also known as N-acetyl-1H-benzimidazole-2-one, is an organic compound derived from benzimidazole. It is commonly used in the pharmaceutical and cosmetic industries as a chemical intermediate for the synthesis of pharmaceuticals and fragrances. This white crystalline powder is insoluble in water but soluble in organic solvents and is often used as a building block in the production of anti-inflammatory drugs, analgesics, and anti-allergy medications. It is also utilized in sunscreen formulations and other cosmetic products for its UV-absorbing properties. However, it is important to handle 2-Acetylbenzimidazole with care as it may cause skin irritation and allergic reactions.

Upstream product

• 2849-93-6 2-benzimidazolecarboxylic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 51-17-2 benzoimidazole 
• 64-19-7 acetic acid 
• 1029649-48-6 tert-butyl (2-isocyanophenyl)carbamate 
• 31892-41-8 N-cyano-benzimidazole 
• 6299-92-9 1-aminobenzimidazole 
• 546-67-8 lead(IV) tetraacetate 
• 71-43-2 benzene 
• 4746-67-2 benzimidazoline 
• 583-39-1 2,3-dihydrobenzimidazol-2-thione 

Downstream Products

• 1258323-08-8 (E)-methyl 2-((1-benzimidazolyl)methyl)-3-(p-tolyl)acrylate 
• 862995-20-8 (E)-methyl 2-((1-benzimidazolyl)methyl)-3-phenylacrylate 
• 122-79-2 Phenyl acetate 
• 104057-82-1 1,3-diphenyl 9-acetyl-1H,9H-1,2,4-triazolo<4,3-a>benzimidazole 
• 78-93-3 butanone 
• 57301-60-7 5-acetyl-1-benzhydrylidene-4,4-diphenyl-4a,5-dihydro-4H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-3-one 

Relevant articles and documents

Effect of the Leaving Group in the Hydrolysis of N-Acylimidazoles. The Hydroxide Ion, Water, and General Base Catalyzed Hydrolysis of N-Acyl-4(5)-nitroimidazoles

The second-order rate constants kOH for hydroxide ion catalyzed hydrolysis of N-acylimidazoles substituted in the imidazole group show only a moderate dependence on the pKa of the leaving group (βlg = -0.28), which indicat

N-Acylazole mediated stereoselective and regioselective synthesis of N-substituted azole acrylonitriles

Regio- and stereoselective synthesis of N -substituted azole acrylonitriles has been achieved smoothly in N, N -dimethylformamide (DMF) in the presence of potassium carbonate (K 2 CO 3) as a base catalyst. N -Substituted azole acrylonitriles were obtained

A azole amide preparation method of the compound

A preparation method of an azole-series amide compound. The invention discloses a method including a reaction that the azole-series amide is synthesized from a carboxylic acid compound and an azole compound with a copper salt as a catalyst and molecular o