187827-14-1

Basic information

• Product Name: ethyl (E)-3-amino-3-cyclopropyl-prop-2-enoate
• Synonyms: 2-propenoic acid, 3-amino-3-cyclopropyl-, ethyl ester, (2E)-; Ethyl (2E)-3-amino-3-cyclopropylacrylate; ethyl 3-amino-3-cyclopropylacrylate
• CAS NO: 187827-14-1
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19
• Mol File: 187827-14-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 262.5°C at 760 mmHg
• Flash Point: 124.6°C
• Density: 1.128g/cm³
• Vapor Pressure: 0.0109mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: ethyl (E)-3-amino-3-cyclopropyl-prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (E)-3-amino-3-cyclopropyl-prop-2-enoate(187827-14-1)
• EPA Substance Registry System: ethyl (E)-3-amino-3-cyclopropyl-prop-2-enoate(187827-14-1)

Safety Data

• Hazardous Substances Data: 187827-14-1(Hazardous Substances Data)

Upstream product

• 24922-02-9 Ethyl 3-cyclopropyl-3-oxopropionate 
• 765-43-5 Cyclopropyl methyl ketone 
• 6148-64-7 ethyl potassium malonate 
• 5500-21-0 cyclopropropanecarbonitrile 
• 105-36-2 ethyl bromoacetate 
• 64-17-5 ethanol 
• 77570-23-1 5-(Amino-cyclopropyl-methylene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 

Downstream Products

• 66092-09-9 diethyl 2,5-diphenyl-1H-pyrrole-3,4-dicarboxylate 

Relevant articles and documents

The decarboxylative blaise reaction

(Chemical Equation Presented) Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Huenig's base provided β-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction,

Regioselective Synthesis of N2-Aryl 1,2,3-Triazoles via Electro-oxidative Coupling of Enamines and Aryldiazonium Salts

An efficient synthetic route for the construction of N2-aryl 1,2,3-triazoles is reported via sequential C-N bond formation and electro-oxidative N-N coupling under metal-free conditions. Readily accessible 2-aminoacrylates and aryldiazonium salts were used as starting materials, and the developed protocol displays excellent functional group tolerance, allowing an extensive range of substrate scope up to 91% isolated yield. Various mechanistic studies, along with the isolation of an intermediate adduct, refer to successive ionic and radical reaction sequences.

Phenyl derivatives, their manufacture and use as pharmaceutical agents

This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.