187844-34-4Relevant academic research and scientific papers
Convenient synthesis of 2,2-disubstituted-2,3-dihydro-1,4-benzodioxins from 2-substituted-2-hydroxy-2,3-dihydro-1,4-benzodioxins
Thiery, Valerie,Coudert, Gerard,Guillaumet, Gerald
, p. 2061 - 2074 (2007/10/03)
Convenient syntheses of relatively rare 2,2-disubstituted-2,3-dihydro-1,4-benzodioxins from 2-substituted-2-hydroxy-2,3-dihydro-1,4-benzodioxins, as key synthetic intermediates, are reported. These new synthetic approaches require Lewis acid BF3-Et2O mediated nucleophilic substitution reaction or cyclization of suitable hydroxyphenols.
α-Adrenoreceptor Reagents. 3. Synthesis of Some 2-Substituted 1,4-Benzodioxans as Selective Presynaptic α2-Adrenoreceptor Antagonists
Stillings, Michael R.,Chapleo, Christopher B.,Butler, Richard C. M.,Davis, J. Alfred,England, C. David,et al.
, p. 1054 - 1062 (2007/10/02)
The synthesis and pharmacological activity of a series of 2-substituted derivatives of the selective α2-adrenoreceptor antagonist idazoxan (RX 781094) is described.Substitution in this position by alkyl, alkenyl, cycloalkenyl, and alkoxy groups in many cases gives compounds whose potencies and selectivities are significantly greater than those of the parent compound.
