5770-58-1Relevant academic research and scientific papers
Iridium-catalyzed asymmetric hydrogenation of 2-substituted 1,4-benzodioxines
Wang, Yanzhao,Xia, Jingzhao,Yang, Guoqiang,Zhang, Wanbin
, p. 477 - 482 (2017/12/26)
An Ir-catalyzed asymmetric hydrogenation of 2-substituted 1,4-benzodioxines was developed for the preparation of chiral 1,4-benzodioxanes, which are present in numerous biologically active compounds and natural products. Our tropos biphenyl phosphine-oxazoline ligand is essential for obtaining good ee. A broad range of substrates were tolerable to the reaction conditions and gave the corresponding hydrogenation products in excellent yields and with moderate to good enantioselectivities using the Ir-complex of our tropos phosphine-oxazoline ligand.
Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
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Page/Page column 32, (2008/06/13)
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.
Convenient synthesis of 2,2-disubstituted-2,3-dihydro-1,4-benzodioxins from 2-substituted-2-hydroxy-2,3-dihydro-1,4-benzodioxins
Thiery, Valerie,Coudert, Gerard,Guillaumet, Gerald
, p. 2061 - 2074 (2007/10/03)
Convenient syntheses of relatively rare 2,2-disubstituted-2,3-dihydro-1,4-benzodioxins from 2-substituted-2-hydroxy-2,3-dihydro-1,4-benzodioxins, as key synthetic intermediates, are reported. These new synthetic approaches require Lewis acid BF3-Et2O mediated nucleophilic substitution reaction or cyclization of suitable hydroxyphenols.
SYNTHETIC STUDIES ON 1,4-BENZODIOXIN: THE PREPARATION OF ANALOGUES OF BIOLOGICALLY IMPORTANT INDOLES
Lee, Thomas V.,Leigh, Alistair J.,Chapleo, Christopher B.
, p. 921 - 934 (2007/10/02)
The expectation that some benzodioxin derivatives are potentially pharmacologically valuable has led to the development of new chemistry for the construction and functionalisation of the benzodioxin moiety.This includes the preparation of 2-bromo-1,4-benz
DEHYDRATION OF SUBSTITUTED 2,3-DIHYDRO-1,4-BENZODIOXIN-2-OLS BY ACETIC ANHYDRIDE
Dzvinchuk, I. B.,Lozinskii, M. O.
, p. 1142 - 1145 (2007/10/02)
The dehydration of 2,3-dihydro-1,4-benzodioxin-2-ols substituted in the heterocycle, which exist in equilibrium with the noncyclic tautomer in solutions, was studied.It takes place through stabilization of the cyclic tautomeric form by O-acetylation and s
Synthesis, Thermal Stability, and Chemiluminescence Properties of the Dioxetanes Derived from 1,4-Dioxines
Adam, Waldemar,Peters, Eva-Maria,Peters, Karl,Platsch, Herbert,Schmidt, Ernst,et al.
, p. 3920 - 3928 (2007/10/02)
Photosensitized oxygenation of benzo- and naphtho-1,4-dioxins 3 afforded the corresponding 1,2-dioxetanes 4 in moderate to good yields.Ene products 7 were obtained in those cases in which the 1,4-dioxins 3 bear alkyl substituents.Thermal decomposition of the 1,2-dioxetanes 4 afford the corresponding diesters 5 essentially quantitatively.The X-ray crystal structures of the dioxetanes 4g, 4h, and 4j indicate that the four-membered rings are all essentially planar.These dioxetanes exhibit surprisingly similar thermal stabilities; the free energies of activation (ΔG(excit.)) at 298 K fall within 26 +/- 1 kcal/mol, the enthalpies of activation (ΔH(excit.)) within 24 +/- 1.5 kcal/mol, and the entropies of activation (ΔS(excit.)) within -6 +/- 2 eu.In their chemiluminescence properties they are inefficient sources of chemienergized, electronically excited diester products.The singlet excitation yields (ΦS) range between 0.0001percent and 0.003percent and the triplet excitation yields (ΦT) between 0.01percent and 3.5percent.They represent typical dioxetanes in that preferentially triplet excited carbonyl products are chemienergized.
Bis(3-phenyl-1,4-benzodioxin-2-yl) Sulfide: Formation and Structure Elucidation
Adam, Waldemar,Peters, Eva-Maria,Peters, Karl,Schmidt, Ernst,Schnering, Hans Georg von
, p. 1686 - 1689 (2007/10/02)
Bei der Darstellung von 2-Phenyl-1,4-benzodioxin (2) durch Dehydratisierung von 2,3-Dihydro-2-hydroxy-2-phenyl-1,4-benzodioxin (1) mittels Thionylchlorid in Pyridin bei 120-130 Grad C wird als Nebenprodukt Bis(3-phenyl-1,4-benzodioxin-2-yl)sulfid (3) gebi
