18797-86-9

Basic information

• Product Name: QUININE ACETATE
• Synonyms: QUININE ACETATE;acetylquinine;(8α,9R)-acetate- 6'-Methoxy-Cinchonan-9-ol;(8α,9R)-6'-Methoxycinchonan-9-ol Acetate;(8α,9R)-6'-Methoxycinchonan-9-ol Acetate,99%d.e.
• CAS NO: 18797-86-9
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 384.47
• Mol File: 18797-86-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 496.2°Cat760mmHg
• Flash Point: 253.9°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 5.5E-10mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: QUININE ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: QUININE ACETATE(18797-86-9)
• EPA Substance Registry System: QUININE ACETATE(18797-86-9)

Safety Data

• Hazardous Substances Data: 18797-86-9(Hazardous Substances Data)

Usage

General Description

Quinine acetate is a salt compound derived from the natural alkaloid quinine, which is traditionally extracted from the bark of the cinchona tree. Quinine acetate is commonly used as a medication to treat malaria and has also been used in the treatment of nocturnal leg cramps. It works by killing the malaria parasites and preventing their growth in the body. Quinine acetate is classified as an antimalarial drug and is typically administered orally in the form of tablets or capsules. However, due to its potential side effects and interactions with other medications, it is important for patients to use quinine acetate under the guidance and supervision of a healthcare professional.

InChI:InChI=1/C22H26N2O3/c1-4-15-13-24-10-8-16(15)11-21(24)22(27-14(2)25)18-7-9-23-20-6-5-17(26-3)12-19(18)20/h4-7,9,12,15-16,21-22H,1,8,10-11,13H2,2-3H3/t15-,16+,21-,22+/m0/s1

Upstream product

• 108-24-7 acetic anhydride 
• 130-95-0 quinine 
• 75-36-5 acetyl chloride 
• 122-79-2 Phenyl acetate 
• 130-95-0 Quinine 
• 830-03-5 4-nitrophenol acetate 
• 64-19-7 acetic acid 

Downstream Products

• 130-95-0 quinine 
• 73489-79-9 (R)-1-{(1S,3R,4S)-6-[(S)-Hydroxy-(6-methoxy-quinolin-4-yl)-methyl]-1-aza-bicyclo[2.2.2]oct-3-yl}-ethane-1,2-diol 
• 73489-79-9 (S)-1-{(1S,3R,4S)-6-[(S)-Hydroxy-(6-methoxy-quinolin-4-yl)-methyl]-1-aza-bicyclo[2.2.2]oct-3-yl}-ethane-1,2-diol 

Relevant articles and documents

Synthesis and biological activity of fatty acid derivatives of quinine

Derivatives of quinine with fatty acids including polyunsaturated fatty acids were prepared. They showed moderate antimalarial activity as compared with quinine itself using Plasmodium falciparum. The activities were not dependent on whether the fatty acyl group was saturated or unsaturated. On the other hand, the derivatives showed significantly higher cytotoxicity against a mammary tumor cell line FM3A than quinine itself. Calculating from these data, an acetyl derivative of quinine with the shortest acyl group was found to give the highest selectivity.

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9R-acyloxy quinine derivatives, preparation method therefor, application of quinine or derivatives thereof and botanical insecticides

The invention relates to 9R-acyloxy quinine derivatives, a preparation method therefor, an application of quinine or derivatives thereof and botanical insecticides and belongs to the technical field of botanical pesticides. The 9R-acyloxy quinine derivatives disclosed by the invention are prepared through subjecting the quinine and R-COOH to an esterification reaction, have remarkable insecticidalactivity to Lepidoptera agricultural insect pests and have a remarkable control efficiency to armyworms of Lepidoptera, and part of the 9R-acyloxy quinine derivatives have an armyworm control efficiency already exceeding that of a commercialized botanical insecticide, i.e., toosendanin and can be applied to preparation of botanical insecticides for the Lepidoptera agricultural insect pests. In the prior art, the quinine is mainly used for treating human diseases induced by Plasmodium falciparum; and in the invention, discovered through researches, the quinine also has a relatively good control action on the Lepidoptera agricultural insect pests and has a remarkable control efficiency to the armyworms.

Catalytic Difluorination of Olefins

Molecular editing with fluorine is a validated strategy for modulating the structure and function of organic systems. In the current arsenal of catalytic dihalogenation technologies, the direct generation of the vicinal difluoride moiety from simple olefins without a prefunctionalization step remains conspicuously absent. Herein we report a catalytic, vicinal difluorination of olefins displaying broad functional group tolerance, using inexpensive p-iodotoluene as the catalyst. Preliminary efforts toward the development of an enantioselective variant are also disclosed.