18797-91-6Relevant academic research and scientific papers
Rhodium-catalyzed asymmetric hydrogenation of β-branched enamides for the synthesis of β-stereogenic amines
Zhang, Jian,Liu, Chong,Wang, Xingguang,Chen, Jianzhong,Zhang, Zhenfeng,Zhang, Wanbin
supporting information, p. 6024 - 6027 (2018/06/18)
Using a rhodium complex of a bisphosphine ligand (R)-SDP, β-branched simple enamides with a (Z)-configuration were hydrogenated to β-stereogenic amines in quantitative yields and with excellent enantioselectivities (88-96% ee).
Novel chiral phosphine ligand, metal catalyst containing chiral phosphine ligand and preparation method and application thereof
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, (2016/11/21)
The invention provides a novel chiral phosphine ligand, a metal catalyst containing the chiral phosphine ligand and a preparation method and an application thereof. The novel chiral phosphine ligand has a structural formula shown in the attached figure; the metal catalyst is a transition metal complex which is synthesized by the novel chiral phosphine ligand and transition metal, and is used for asymmetric catalyzing and hydrogenating reaction, and catalyzing and hydrogenating to synthesize beta-arylamide with high optical purity. The novel chiral phosphine ligand has the advantages that the economic practicality is higher, the product purity is high, the carrying amount of ligand (S/C) is high, and the like.
