188047-59-8

Basic information

• Product Name: C₁₂H₈ClN₃OS
• Synonyms: C₁₂H₈ClN₃OS
• CAS NO: 188047-59-8
• Molecular Weight: 277.734
• Mol File: 188047-59-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₈ClN₃OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₈ClN₃OS(188047-59-8)
• EPA Substance Registry System: C₁₂H₈ClN₃OS(188047-59-8)

Safety Data

• Hazardous Substances Data: 188047-59-8(Hazardous Substances Data)

Upstream product

• 89-25-8 edaravone 
• 100-63-0 phenylhydrazine 
• 1140-38-1 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4?carboxylic acid 
• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 188047-58-7 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4?carbonyl chloride 

Downstream Products

• 1392131-65-5 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-67-7 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-63-3 1-(4-bromo-2-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-64-4 1-(2-fluorobenzyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-66-6 1-(2-fluoro-3-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1190107-86-8 C₃₆H₂₈Cl₂N₈O₂S₂ 
• 1190107-85-7 C₃₀H₂₄Cl₂N₈O₂S₂ 
• 1190107-83-5 C₃₀H₂₄Cl₂N₈O₂S₂ 
• 1190107-84-6 C₃₀H₂₄Cl₂N₈O₂S₂ 
• 1190107-87-9 C₃₈H₃₂Cl₂N₈O₂S₂ 

Relevant articles and documents

Synthesis and bioactivity of pyrazole acyl thiourea derivatives

Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3- methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3- methyl -1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, 1H-NMR, 13C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests.