188751-54-4

Usage

Uses

Used in Organic Synthesis:
1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is utilized as an intermediate in the development of new drugs and pharmaceuticals. Its unique structure makes it a promising candidate for creating novel therapeutic agents.
Used in Drug Development:
1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is employed in drug development for its potential to contribute to the creation of innovative medications, particularly due to its compatibility with a range of chemical processes and its ability to enhance the properties of other compounds in formulations.

Upstream product

• 124-38-9 carbon dioxide 
• 182344-70-3 5-bromo-indole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 777061-36-6 1,1-dimethylethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate 
• 272438-11-6 1-tert-butoxycarbonyl-5-methoxycarbonylindole 

Relevant academic research and scientific papers

Method for preparing aromatic carboxylic acid compound

The invention discloses a method for preparing an aromatic carboxylic acid compound. The method comprises the following steps: 1) heating carbon dioxide and hydrosilane in the presence of a copper catalyst in a reaction medium A; and 2) adding a reaction medium B, aryl halide, a palladium catalyst and a base to the reaction mixture in the step 1), sealing the reaction system, and performing a heating reaction. The method has the advantages that raw materials are simple and easy to obtain, the raw materials are cheap and stable, the catalyst is common, easy to obtain and stable, the reaction conditionsaremild, the aftertreatment is simple, the yield is high, and the like.

Tandem one-pot CO2 reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids

The present study discloses the synthesis of aryl/vinyl carboxylic acids from Csp2-bound halides (Cl, Br, I) in a carbonylative path by using silyl formate (from CO2 and hydrosilane) as an instant CO-surrogate. Hydrosilane provides hydride for reduction and its oxidation product silanol serves as a coupling partner. Mono-, di-, and tri-carboxylic acids were obtained from the corresponding aryl/vinyl halides.

Visible-Light-Driven Carboxylation of Aryl Halides by the Combined Use of Palladium and Photoredox Catalysts

A highly useful, visible-light-driven carboxylation of aryl bromides and chlorides with CO2 was realized using a combination of Pd(OAc)2 as a carboxylation catalyst and Ir(ppy)2(dtbpy)(PF6) as a photoredox catalyst. This carboxylation reaction proceeded in high yields under 1 atm of CO2 with a variety of functionalized aryl bromides and chlorides without the necessity of using stoichiometric metallic reductants.