18877-33-3

Basic information

• Product Name: N-(2-Nitrobenzoyl)-L-proline
• Synonyms: N-(2-Nitrobenzoyl)-L-proline
• CAS NO: 18877-33-3
• Molecular Formula: C₁₂H₁₂N₂O₅
• Molecular Weight: 264.23
• Product Categories: pharmacetical
• Mol File: 18877-33-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 523.1°Cat760mmHg
• Flash Point: 270.2°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 9.02E-12mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: N-(2-Nitrobenzoyl)-L-proline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Nitrobenzoyl)-L-proline(18877-33-3)
• EPA Substance Registry System: N-(2-Nitrobenzoyl)-L-proline(18877-33-3)

Safety Data

• Hazardous Substances Data: 18877-33-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H12N2O5/c15-11(13-7-3-6-10(13)12(16)17)8-4-1-2-5-9(8)14(18)19/h1-2,4-5,10H,3,6-7H2,(H,16,17)/t10-/m0/s1

Upstream product

• 552-16-9 ortho-nitrobenzoic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 147-85-3 L-proline 

Downstream Products

• 105089-64-3 N-(2-nitrobenzoyl)-L-proline methyl ester 
• 105089-65-4 (2S)-N-(2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 105089-66-5 (2S)-N-(2-aminobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 72435-89-3 (11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 
• 154078-66-7 (S)-1-(2-Amino-benzoyl)-pyrrolidine-2-carboxylic acid (4-methoxy-phenyl)-amide 
• 176387-45-4 (S)-1-(2-Nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde 
• 72435-94-0 (S)-N-(2-nitrobenzyl)pyrrolidine-2-carboxaldehyde 

Relevant articles and documents

A convenient synthesis of chiral 2-methylenebenzo[e][1,4]diazepin-5-ones via a one-pot reductive cyclodehydration with retention of chirality

Total synthesis of optically pure (+)-Fuligocandin A from L-proline has been achieved in 29% overall yield. The key step, one-pot reductive cyclodehydration of the chiral 2-nitrophenyl-1,3-dicarbonyl compound, proceeds with >98% retention of configuration

Synthesis of actinomycin related compounds. I.

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