188943-06-8

Basic information

• Product Name: 2'-methyl-, methyl ester
• Synonyms: 2'-methyl-, methyl ester
• CAS NO: 188943-06-8
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27046
• Mol File: 188943-06-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-methyl-, methyl ester(188943-06-8)
• EPA Substance Registry System: 2'-methyl-, methyl ester(188943-06-8)

Safety Data

• Hazardous Substances Data: 188943-06-8(Hazardous Substances Data)

Usage

Uses

Methyl 2''-Methyl-[1,1''-biphenyl]-2-carboxylate is a reagent for the synthesis of nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors.

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 342-54-1 2-(methoxycarbonyl)benzenediazonium tetrafluoroborate 
• 95-46-5 2-methylphenyl bromide 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 51471-72-8 (2-methoxycarbonyl-phenylsulfanyl)-acetic acid 
• 7029-31-4 bis(2-methylphenyl)zinc 
• 66107-34-4 2-methylphenyl triflate 
• 51207-44-4 methyl 2-{[(4-methylphenyl)sulfonyl]oxy}benzoate 
• 88-65-3 2-bromobenzoic-acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 13029-09-9 2,2'-dibromobiphenyl 
• 79-22-1 methyl chloroformate 
• 74-88-4 methyl iodide 

Downstream Products

• 484-17-3 9-Phenanthrol 
• 60848-13-7 N-methylphenanthren-9-amine 
• 7111-68-4 2'-methylbiphenyl-2-carboxaldehyde 
• 1859-10-5 4-methylfluoren-9-ol 
• 158443-23-3 tricarbonylchrominum(methyl 2'-methyl-1,1'-biphenyl-2-carboxylate) 
• 73527-16-9 bis(tricarbonylchrominum)(methyl 2'-methyl-1,1'-biphenyl-2-carboxylate) 
• 7111-77-5 2'-methyl[1,1'-biphenyl]-carboxylic acid 

Relevant articles and documents

Dual Nickel-/Palladium-Catalyzed Reductive Cross-Coupling Reactions between Two Phenol Derivatives

Cross-coupling between substrates that can be easily derived from phenols is highly attractive due to the abundance of phenols. Here, we report a dual nickel-/palladium-catalyzed reductive cross-coupling between aryl tosylates and aryl triflates; both substrates can be accessed in just one step from readily available phenols. The reaction has a broad functional group tolerance and substrate scope (>60 examples). Furthermore, it displays low sensitivity to steric effects demonstrated by the synthesis of a 2,2′-disubstituted biaryl and a fully substituted aryl product. The widespread presence of phenols in natural products and pharmaceuticals allows for straightforward late-stage functionalization, illustrated with examples such as ezetimibe and tyrosine.

Exploration of Biaryl Carboxylic Acids as Proton Shuttles for the Selective Functionalization of Indole C-H Bonds

A survey of diversely substituted 2-arylbenzoic acids were synthesized and tested for use as proton shuttle in the direct arylation of indoles with bromobenzenes. It was found that 3-ethoxy-2-phenylbenzoic acid gives superior yield and selectivity for this class of substrates.

Synthesis of fluorenones through rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids

An efficient approach to the synthesis of fluorenones via the rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids was developed. Using this procedure, fluorenones with various substituents can be synthesized in good to high yields. This work marks the first recorded use of catalytic intramolecular acylation to synthesize fluorenones.