18908-16-2Relevant articles and documents
MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction
Chen, Xiang,Chen, Yi-Hung,Liu, Shanshan,Shen, Xiao,Zhu, Zhihong
supporting information, (2021/11/27)
Herein, we report an unprecedented regiospecific oxidative Mizoroki-Heck type reaction for the synthesis of ɑ-difluoromethyl homoallylic alcohols. The reaction shows broad substrate scopes and high functional group tolerance. Late-stage functionalization of complex biologically active molecules demonstrates the synthetic potential of this transformation. Mechanistic study supports the involvement of MnBr2 catalyzed radical 1,2-silyl transfer.
Iodothiocyanation/Nitration of Allenes with Potassium Thiocyanate/Silver Nitrite and Iodine
Yang, Xiaodong,She, Yue,Chong, Ya,Zhai, Huichun,Zhu, He,Chen, Baohua,Huang, Guosheng,Yan, Rulong
supporting information, p. 3130 - 3134 (2016/10/09)
Direct strategies for the iodothiocyanation and iodonitration of allenes have been developed. In this process, potassium thiocyanate/silver nitrite and molecular iodine are used as the source of SCN, ONO2and iodine to provide the desired products in moderate to good yields with high stereoselectivity. (Figure presented.).
Solvolysis of 2-chloro-2(3,4-disubstituted) phenylpropanes: Validity of Hammett-Brown σ+ constants in assessing additive effects of substituents
Taha, Ahmed A.
, p. 514 - 523 (2012/07/28)
The objective of this study is to test the suitability of the extended Hammett-Brown equation, log (kXX/kHH) = ρ+∑σ+, in depicting satisfactorily additive effects of electronegative atom-bearing substituents, which are known to possess diverse and multicomponent influences on the side chain reactions of polysubstituted benzenes. The equation has been used to correlate, for the first time, the additive effect of substituents in the specific rates of solvolysis of 2-chloro-2-phenylpropanes (3b-3f) having 3-F,4-Me, 3-Br,4-Me, 3-I,4-Me, 3-Me,4-Me, or 3-MeO,4-Me substituents. The rates were determined titrimetrically at 288, 298, and 308 K using 90% aqueous acetone as solvent. Measured additive effects of these substituents on the solvolysis rate and activation parameters of the parent cumyl chloride (2-chloro-2-phenylpropane) are found to be well correlated using the equation given above. Plots of log (kXX/k HH) of 3b-3f together with mainly di-, but also tri- and mono-substituted cumyl chlorides from previous studies against ∑σ+ give a linear correlation coefficient of 0.990 as a measure of the validity of the equation to depict such systems. The halogen substituents' extent of conformity with additivity reflected in their relative (kobsd/kcalcd) rate ratios is found to correlate with the steric size of substituents. Plots of rate ratios against Taft's steric factor of each halogen give a linear correlation coefficient of 0.994 for the 3-halo substituents. The 3,4-dimethyl substituents' relative rate ratio of 1.03 shows excellent additivity, whereas the 3-methoxy-4-methyl ratio of 1.43 shows the methoxy group to be far less deactivating than predicted. Similar trends were found for the free energy of activation (δG? - δG 0?) differences, which correlated linearly with a coefficient of 0.983 with Taft's steric factor of halogen atoms.