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33967-19-0

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33967-19-0 Usage

Description

Medetomidine Impurity 2, also known as 1-(3,4-Dimethylphenyl)ethanol, is an intermediate in the production of Medetomidine (M203250), an α2-Adrenergic agonist. It plays a crucial role in the synthesis of Medetomidine, which is a sedative and analgesic agent.

Uses

Used in Pharmaceutical Industry:
Medetomidine Impurity 2 is used as an intermediate in the production of Medetomidine, an α2-Adrenergic agonist, for its sedative and analgesic properties. It contributes to the development of medications that help in calming and alleviating pain in various medical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 33967-19-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,9,6 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 33967-19:
(7*3)+(6*3)+(5*9)+(4*6)+(3*7)+(2*1)+(1*9)=140
140 % 10 = 0
So 33967-19-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H14O/c1-7-4-5-10(9(3)11)6-8(7)2/h4-6,9,11H,1-3H3

33967-19-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3,4-Dimethylphenyl)ethanol

1.2 Other means of identification

Product number -
Other names 3',4'-dimethylphenylethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33967-19-0 SDS

33967-19-0Relevant articles and documents

FLP-Catalyzed Transfer Hydrogenation of Silyl Enol Ethers

Khan, Imtiaz,Reed-Berendt, Benjamin G.,Melen, Rebecca L.,Morrill, Louis C.

, p. 12356 - 12359 (2018/09/18)

Herein we report the first catalytic transfer hydrogenation of silyl enol ethers. This metal free approach employs tris(pentafluorophenyl)borane and 2,2,6,6-tetramethylpiperidine (TMP) as a commercially available FLP catalyst system and naturally occurring γ-terpinene as a dihydrogen surrogate. A variety of silyl enol ethers undergo efficient hydrogenation, with the reduced products isolated in excellent yields (29 examples, 82 % average yield).

Dynamic path bifurcation in the Beckmann reaction: Support from kinetic analyses

Yamamoto, Yutaro,Hasegawa, Hiroto,Yamataka, Hiroshi

, p. 4652 - 4660 (2011/07/29)

The reactions of oximes to amides, known as the Beckmann rearrangement, may undergo fragmentation to form carbocations + nitriles when the migrating groups have reasonable stability as cations. The reactions of oxime sulfonates of 1-substituted-phenyl-2-propanone derivatives (7-X) and related substrates (8-X, 9a-X) in aqueous CH3CN gave both rearrangement products (amides) and fragmentation products (alcohols), the ratio of which depends on the system; the reactions of 7-X gave amides predominantly, whereas 9a-X yielded alcohols as the major product. The logk-logk plots between the systems gave excellent linear correlations with slopes of near unity. The results support the occurrence of path bifurcation after the rate-determining TS of the Beckmann rearrangement/fragmentation reaction, which has previously been proposed on the basis of molecular dynamics simulations. It was concluded that path-bifurcation phenomenon could be more common than thought and that a reactivity-selectivity argument based on the traditional TS theory may not always be applicable even to a well-known textbook organic reaction.

Preparation of chiral 1-phenylethanols and bromides

Stein, Allan R.,Dawe, Robert D.,Sweet, James R.

, p. 3442 - 3448 (2007/10/02)

A fast, convenient procedure for preparing and resolving moderate to large quantities of chiral secondary alcohols is described.The general procedure involves a one-pot conversion of the ketone (various acetophenones) to the half-ester of a diacid (succinic, phthalic...) and resolution with (+)- and (-)-1-phenylethylamines.Overall yields of the enantiomeric alcohols, the variously substituted 1-phenylethanols, are generally 65-85percent with optical purities of approximately 90percent.Properties and optical rotations of a number of chiral 1-phenylethanols and of the bromides made from them are tabulated.A discussion of optical purity determinations using nmr methods is included and absolute configurations are reported.

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