189100-30-9

Upstream product

• 189100-17-2 3-(4-cyanophenyl)aminopyridine N-oxide 
• 462-08-8 pyridin-3-ylamine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 623-03-0 4-Cyanochlorobenzene 
• 695-37-4 3-fluoropyridine-1-oxide 
• 126747-14-6 4-cyanophenylboronic acid 
• 1016872-53-9 C₁₄H₁₁N₃O₂ 

Downstream Products

• 1268526-18-6 C₂₃H₂₉N₃ 
• 1310693-60-7 5-(5-cyclohexylpentyl)-5H-pyrido[3,2-b]indol-8-carbonitrile 
• 1310693-38-9 8-cyano-5-(5-cyclohexylpentyl)-1-methyl-5H-pyrido[3,2-b]indol-1-ium iodide 

Relevant academic research and scientific papers

A Tetraarylpyrrole-Based Phosphine Ligand for the Palladium-Catalyzed Amination of Aryl Chlorides

A tetraarylpyrrole-based phosphine ligand L1 in combination with Pd(dba)2 provided a catalyst for the Buchwald-Hartwig amination reaction. A variety of amines were rapidly coupled with aryl chlorides at a Pd loading of 0.5 mol%. The selective monoarylation of aliphatic primary amines was achieved in the presence of 0.8 equiv. water. Comparison experiments were also conducted, which revealed that the catalytic activity of L1 is superior to representative phosphine ligands in the Pd-catalyzed C?N coupling of various amines. (Figure presented.).

Heterocyclic triarylamine compound and organic optoelectronic device containing same

The invention provides a heterocyclic triarylamine compound and an organic optoelectronic device containing the heterocyclic triarylamine compound. The heterocyclic triarylamine compound contains a heterocyclic aryl group and an electron withdrawing group

PHOSPHINE COMPOUND, CROSSLINKED COMPOSITION, AND MANUFACTURING METHOD OF AROMATIC AMINE COMPOUND

PROBLEM TO BE SOLVED: To provide a phosphine compound capable of constituting a transition metal complex excellent in reaction speed and selectivity as a catalyst. SOLUTION: There is provided a phosphine compound represented by the formula (I). In the formula Ar represents each independently an aryl group which may be substituted, R1 represents each independently a linear, branched or cyclic alkyl group, R2 represents each independently a linear, branched or cyclic alkyl group, alkoxy group or aryl group which may be substituted, or neighboring 2 R2 are bound each other to form a ring, and n represents an integer of 0 to 4. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Synthesis of N-Azaaryl anilines: An efficient protocol via smiles rearrangement

An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of Nazaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyrido

Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens

Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived.

δ-carbolines and their ring-opened analogs: Synthesis and evaluation against fungal and bacterial opportunistic pathogens

Previous studies have indicated that the δ-carboline (2) ring system derived from the natural product cryptolepine (1) may represent a pharmacophore for anti-infective activity. This paper describes the design and synthesis of a small library of substitut

Palladium-catalyzed couplings of heteroaryl amines with aryl halides using sodium phenolate as the stoichiometric base

Heteroaryl amines are efficiently coupled (in two hours) to aryl halides with catalytic Pd2(dba)3 and Xantphos to provide the corresponding biaryl amines under microwave and standard thermal conditions. The use of organic-soluble sodium phenolate (NaOPh) as the stoichiometric base promotes facile coupling of a variety of substrates in excellent yields. Georg Thieme Verlag Stuttgart.

Studies on aromatase inhibitors. III. Synthesis and biological evaluation of [(4-bromobenzyl)(4-cyanophenyl)amino]azoles and their azine analogs

A series of [(4-bromobenzyl)(4-cyanophenyl)amino]azoles and their azine analogs, which have the side chain of the selective aromatase inhibitor YM511, were synthesized and evaluated for aromatase-inhibitory activity (in vitro) and for pregnant mare serum