18921-68-1 Usage
General Description
Deaza-Aminopterin is a synthetic derivative of the drug aminopterin, which acts as an inhibitor of the enzyme dihydrofolate reductase. This enzyme is involved in the synthesis of nucleic acids, specifically DNA and RNA, making it a key target for cancer chemotherapy. Deaza-Aminopterin works by blocking the synthesis of nucleic acids, leading to a disruption in the growth and proliferation of cancer cells. It has shown promising results in preclinical studies as a potential treatment for various types of cancer, including acute lymphoblastic leukemia, non-Hodgkin's lymphoma, and solid tumors. Despite its potential as a chemotherapy agent, further research is still needed to assess its efficacy and safety in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 18921-68-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,2 and 1 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18921-68:
(7*1)+(6*8)+(5*9)+(4*2)+(3*1)+(2*6)+(1*8)=131
131 % 10 = 1
So 18921-68-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H22N6O5/c22-18-14-9-11(1-6-15(14)26-21(23)27-18)10-24-13-4-2-12(3-5-13)19(30)25-16(20(31)32)7-8-17(28)29/h1-6,9,16,24H,7-8,10H2,(H,25,30)(H,28,29)(H,31,32)(H4,22,23,26,27)
18921-68-1Relevant articles and documents
Chemistry and Antitumor Evaluation of Selected Classical 2,4-Diaminoquinazoline Analogues of Folic Acid
Hynes, J.B.,Harmon, S.J.,Floyd, G.G.,Farrington, M.,Hart, L.D.,et al.
, p. 209 - 215 (2007/10/02)
A series of six 2,4-diaminoquinazoline analogues of folic acid which bear close structural resemblance to methotrexate, 1a, were synthesized by unequivocal routes.Three of these have not been described previously, while complete structural characterizatio