18933-87-4

Upstream product

• 98-88-4 benzoyl chloride 
• 142386-46-7 2,3,4,2',3',4'-hexakis-O-benzoyl-α,α-D-trehalose 
• 100-52-7 benzaldehyde 
• 99-20-7 TREHALOSE 
• 18933-86-3 6,6'-dibromo-2,3,4,2',3',4'-hexa-O-benzoyl-6,6'-dideoxy-α,α-trehalose 
• 577969-86-9 2,3,2',3'-tetra-O-benzoyl-4,6:4',6'-di-O-benzylidene-α,α-trehalose 
• 18929-82-3 4,6;4',6'-di-O-benzylidene-α,α-D-trehalose 

Downstream Products

• 30923-00-3 6,6'-diamino-6,6'-dideoxy-α,α-D-trehalose 
• 428509-08-4 2,3,4,2',3',4'-hexa-O-benzoyl6,6'-dideoxy-6,6'-bis[(phenylsulfonyl)amino]-α,α-trehalose 
• 428509-05-1 2,3,4,2',3',4'-hexa-O-benzoyl-6,6'-bis[(1-butylsulfonyl)amino]-6,6'-dideoxy-α,α-trehalose 
• 428509-06-2 2,3,4,2',3',4'-hexa-O-benzoyl-6,6'-bis[(1-octylsulfonyl)amino]-6,6'-dideoxy-α,α-trehalose 
• 18933-88-5 6-azido-6-deoxy-α-D-glucopyranosyl-(1→1)-6-azido-6-deoxy-α-D-glucopyranoside 

Relevant academic research and scientific papers

Design of Trehalose-Based Amide/Sulfonamide C-type Lectin Receptor Signaling Compounds

Mincle agonists have been shown to induce inflammatory cytokine production, such as tumor necrosis factor-alpha (TNF) and promote the development of a Th1/Th17 immune response that might be crucial to development of effective vaccination against pathogens

DIARYL TREHALOSE COMPOUNDS AND USES THEREOF

Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis

Analogs of trehalose are reported that were designed to interfere with mycolylation pathways in the mycobacterial cell wall. Several derivatives of 6,6′-dideoxytrehalose, including N,N′-dialkylamino and 6,6′-bis(sulfonamido) analogs, were prepared and evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Ra and a panel of clinical isolates of Mycobacterium avium. 6,6′-Diaminotrehalose and its diazido precursor were both inactive, but significant activity apparently related to aliphatic chain length was found among the sulfonamides, N-alkylamines, and one of the amidines.