189331-47-3

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-3-METHYL-5-FORMYLTHIOPHENE is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows it to be a key component in the creation of various medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-3-METHYL-5-FORMYLTHIOPHENE is utilized as a precursor in the synthesis of agrochemicals, playing a crucial role in the development of pesticides, herbicides, and other crop protection products.
Used in Fine Chemicals Industry:
2-BROMO-3-METHYL-5-FORMYLTHIOPHENE is employed as a building block in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and specialty chemicals.
Used as a Chemical Intermediate:
2-BROMO-3-METHYL-5-FORMYLTHIOPHENE is also used as a chemical intermediate in the production of a variety of organic compounds, facilitating the synthesis of complex molecules for diverse applications across different industries.

InChI:InChI=1/C6H5BrOS/c1-4-2-5(3-8)9-6(4)7/h2-3H,1H3

Upstream product

• 14282-76-9 2-bromo-3-methylthiophene 
• 6030-36-0 4-methylthiophene-2-carbaldehyde 
• 109-89-7 diethylamine 
• 68-12-2 N,N-dimethyl-formamide 
• 616-44-4 3-Methylthiophene 

Downstream Products

• 304854-52-2 5-bromo-4-methyl-2-thiophenecarbonitrile 
• 54796-53-1 5-Bromo-4-methyl-thiophene-2-carboxylic acid 
• 945392-07-4 5-bromo-4-methyl-5-(oxazol-5-yl)-thiophene 
• 654067-69-3 5-[2-(4-diphenylaminophenyl)]-4-methylthiophene-2-carbaldehyde 
• 1254961-57-3 N-(4-(5-(5,5-dimethyl-1,3-dioxan-2-yl)-3-methylthiophen-2-yl)phenyl)-N-phenylnaphthalen-1-amine 
• 1254961-58-4 4-methyl-5-(4-(naphthalen-1-yl(phenyl)amino)phenyl)thiophene-2-carbaldehyde 
• 1254961-59-5 2-((4-methyl-5-(4-(naphthalen-1-yl(phenyl)amino)phenyl)thiophen-2-yl)methylene)malononitrile 
• 951781-88-7 2-(4-methoxyphenyl)-3-methylthiophene 

Relevant academic research and scientific papers

Preparation method of non-fullerene electronic acceptor, product and application

The material adopts an aromatic or heteroaromatic fused ring to enlarge the planar π-conjugated skeleton as an arm unit, so π-electron delocalization and molecular accumulation are promoted, and the fused ring structure can promote red shift absorption as part of the planar skeleton. The π-extending conjugated structure and the fused ring nucleus rich in the thiophene structure are introduced into the star structure, so that the structure maintains the advantages of strong absorption of the linear structure, easy modification, good thermal stability, strong electron donating capacity, good rigidity and the like.

ACC INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Design of potent and selective hybrid inhibitors of the mitotic kinase nek2: Structure-activity relationship, structural biology, and cellular activity

We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. Structure based design led to aminopyridine (R)-21, a potent and selective inhibitor able to modulate Nek2 activity in cells.

MULTICYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Nonvolatile memory organic field effect transistor induced by the steric hindrance effects of organic molecules

We report a nonvolatile memory organic field effect transistor (OFET) using ambipolar organic molecules as nano-interfaced semiconductor materials. Newly synthesized push-pull organic molecules (PPOMs) containing triarylamine as an electron donating group

Low-cost dyes based on methylthiophene for high-performance dye-sensitized solar cells

Three donor-acceptor, π-conjugated (D-π-A) dyes containing methylthiophene or vinylene methylthiophene as π-conjugated spacer were utilised in dye-sensitized nanocrystalline TiO2 solar cells. The relationship between the structure of the dyes and their photophysical, electrochemical and photovoltaic properties was investigated systematically. The vinyl unit, introduced as the π-conjugated spacer, leads to unfavorable back-electron transfer and decrease of the open-circuit voltage. A dye-sensitized solar cell based on 2-cyano-3-(5-(4-(diphenylamino)phenyl)-4-methylthiophenyl-2-yl) acrylic acid displayed the most efficient solar-to-electricity conversion efficiency of the dyes with a maximum η value of 8.27% (Voc?=?0.72?V, Jsc?=?15.76?mA?cm-2, FF?=?0.73) under simulated AM 1.5 G solar irradiation (100?mW?cm-2).

BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: -COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; R4 and R5: H, optionally substituted alkyl, halogeno, etc.; R6 and R7: H, alkyl; R8: -X2R10 [wherein R10: -COR11 (wherein R11 : OH, optionally substituted alkoxy, optionally substituted amino, etc.), -SO2R12 (wherein R12: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X2: single bond, optionally substituted alkylene, etc.]; X1: -NH-, -O-, -S-, etc.; Y1: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y2: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.

BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS

Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, OH, alkoxy, optionally substituted amino or the like; R3 represents an H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno or the like; R4 and R5 respectively represent an H, optionally substituted alkyl, halogeno or the like; R6 and R7 respectively represent an H or alkyl; R8 represents a -X2R10 [wherein R10 represents a -COR11 (wherein R11 represents an OH, optionally substituted alkoxy, optionally substituted amino or the like), -SO2R12 (wherein R12 represents an optionally substituted alkyl, optionally substituted amino or the like), tetrazole-5-yl or the like; and X2 represents a single bond, optionally substituted alkylene or the like]; X1 represents an -NH-, -O-, -S- or the like; Y1 represents an optionally substituted phenyl or optionally substituted 5-membered or 6-membered aromatic heterocyclyl; and Y2 represents an optionally substituted aryl, substituted heterocyclyl or the like.]

THIENOPYRROLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula I: wherein the dotted lines, U5 V5 X1, Y, R1, R2 and R4 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in

Cyclocarbamate derivatives as progesterone receptor modulators

This invention provides compounds of Formula (I): wherein R1 and R2 may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alkynyl, CORC; RC is H, C1 to C3 alkyl, substituted C1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy, substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R4 is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl, alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R5 is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2, or 3 heteroatoms from the group including O, S, SO, SO2 or NR6 and containing one or two independent substituents from the group including H, halogen, CN, NO2, amino, and C1 to C3 alky, C1 to C3 alkoxy, C1 to C3 aminoalkyl, CORF, or NRGCORF; or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods using the compounds as antagonists of the progesterone receptor.