18955-75-4

Basic information

• Product Name: Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester
• Synonyms: Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester
• CAS NO: 18955-75-4
• Molecular Formula: C₆H₅F₃N₂O₃
• Molecular Weight: 210.1107096
• Mol File: 18955-75-4.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester(18955-75-4)
• EPA Substance Registry System: Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester(18955-75-4)

Safety Data

• Hazardous Substances Data: 18955-75-4(Hazardous Substances Data)

Upstream product

• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 65847-71-4 2-benzofuroyl azide 
• 78140-97-3 2-azidocarbonylbenzothiophene 
• 623-73-4 diazoacetic acid ethyl ester 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1215897-62-3 ethyl 5-(4-fluorophenyl)-2-(trifluoromethyl)furan-3-carboxylate 
• 1215897-57-6 1-(2-ethoxy-5-(4-fluorophenyl)furan-3-yl)-2,2,2-trifluoroethanone 
• 1215897-51-0 1-(5-(4-butylphenyl)-2-ethoxyfuran-3-yl)-2,2,2-trifluoroethanone 
• 1215897-59-8 ethyl 5-(4-butylphenyl)-2-(trifluoromethyl)furan-3-carboxylate 
• 672930-51-7 ethyl 5-phenyl-2-(trifluoromethyl)furan-3-carboxylate 
• 1215897-49-6 1-(2-ethoxy-5-phenylfuran-3-yl)-2,2,2-trifluoroethanone 
• 1215897-55-4 1-(2-ethoxy-5-(4-methoxyphenyl)furan-3-yl)-2,2,2-trifluoroethanone 
• 1215897-61-2 ethyl 5-(4-methoxyphenyl)-2-(trifluoromethyl)furan-3-carboxylate 
• 1215897-60-1 ethyl 5-p-tolyl-2-(trifluoromethyl)furan-3-carboxylate 
• 1215897-53-2 1-(2-ethoxy-5-p-tolylfuran-3-yl)-2,2,2-trifluoroethanone 
• 1287721-43-0 ethyl 4,4,4-trifluoro-2-{[1-(methoxycarbonyl)-2-(phenylthio)vinyl][(2,2,2-trichloroethoxy)carbonyl]amino}-3-oxobutanoate 
• 1354700-12-1 ethyl 4-hydroxy-2-(4-bromophenyl)-4-trifluoromethyl-4,5-dihydrooxazole-5-carboxylate 
• 1354700-14-3 ethyl 2-(4-bromobenzamido)-4,4,4-trifluoro-3,3-dihydroxybutanoate 
• 1354700-22-3 ethyl 2-(4-bromophenyl)-4-trifluoromethyloxazole-5-carboxylate 

Relevant articles and documents

Unexpected trifluoromethylated pyrazoles from ethyl 2-diazo-4,4,4-trifluoroacetoacetate and 1-diethylamino-prop-1-yne

Ethyl 2-diazo-4,4,4-trifluoroacetoacetate reacts with N,N-diethylamino-prop-1-yne via an unusual pathway: the ynamine first reacts with the carbonyl adjacent to CF3, leading to a non-isolated vinyldiazomethane, which undergoes intramolecular cyclisation and then a -shift to afford a pyrazole. - Keywords: Trifluoromethylated pyrazoles; Intramolecular cyclisation; Ynamine reaction; NMR spectroscopy; IR spectroscopy

Synthesis of 3-acyl-5,6-dihydro-1,4-oxathiines through ring expansion of thiiranes

Synthesis of 3-acyl-5,6-dihydro-1,4-oxathiines has been achieved via reactions of thiiranes and α-diazo-β-1,3-dicarbonyl compounds under microwave and copper sulfate-assisted conditions. The current method provides a direct and simple strategy in efficient preparation of 3-acyl-1,4-oxathiines from readily available thiiranes and trans-3-acyl-5,6-dihydro-1,4-oxathiines as stereospecific products for 1,2-disubstituted cis-thiiranes. The reaction mechanism was also proposed.

OXAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.