1897-46-7Relevant academic research and scientific papers
Method for preparing 2, 3, 5, 6-tetrachlorobenzonitrile, special catalyst and preparation method thereof
-
Paragraph 0032; 0034, (2020/09/16)
The invention discloses a method for preparing 2, 3, 5, 6-tetrachlorobenzonitrile, which comprises the following steps: by using 1, 2, 4, 5-tetrachlorobenzene as a raw material, obtaining 2, 3, 5, 6-tetrachlorobenzyl chloride under the action of a special chloromethylation catalyst, and obtaining 2, 3, 5, 6-tetrachlorobenzonitrile under the action of a special ammonia oxidation catalyst. The invention further discloses a special catalyst for preparing 2, 3, 5, 6-tetrachlorobenzonitrile and the preparation method. The special chloromethylation catalyst and the special ammoxidation catalyst havethe advantages of high activity, high product yield, good selectivity, high product purity, long service life and simple process; and the preparation method has the advantages of short reaction route, low reaction temperature, high yield and high selectivity.
Method for preparing polyfluorobenzonitrile through catalytic fluorination of polychlorobenzonitrile
-
Paragraph 0035; 0038-0039; 0069-0071, (2020/04/22)
The invention discloses a method for preparing polyfluorobenzonitrile through catalytic fluorination of polychlorobenzonitrile, and belongs to the field of preparation of fine chemical industry intermediates. The preparation method comprises the following steps: carrying out a heating activation reaction on a fluoride salt, an organic solvent and electron-withdrawing substituted phenylborate; andadding polychlorobenzonitrile, heating to 80-120 DEG C, rectifying while reacting, then supplementing polychlorobenzonitrile and potassium fluoride, and rectifying while reacting to obtain polyfluorobenzonitrile. According to the invention, the reaction system is high in catalytic activity, the technical problems of low conversion rate/medium selectivity and the like of the single nitrile compounds with low activity during fluoridation reactions are solved, the mode simultaneously performing reacting and product distilling in the reaction process promotes the continuous forward proceeding of the reaction so as to improve the reaction yield, and the method is suitable for industrial production.
N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors
-
Page/Page column 41, (2008/12/06)
The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
