189938-86-1Relevant articles and documents
Synthesis and evaluation of halogenated dibenzodiazepines as muscarinic receptor ligands
Kassiou, Michael,Read, Roger W.,Shi, Xue-Qin
, p. 799 - 804 (1997)
Syntheses of four novel amide analogues of the muscarinic M2 receptor antagonists, DIBA and BIBN 140, are described from a common intermediate. Pharmacological evaluation through in vitro assays reveals high muscarinic receptor affinity in each of the compounds, but variable subtype selectivity, primarily M2 but in one case M3.