84200-09-9Relevant articles and documents
Preparation method of piperidine-4-butylamine
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Paragraph 0054; 0072; 0075-0076; 0081; 0084-0085, (2021/07/10)
The invention provides a preparation method of piperidine-4-butylamine, which comprises the following steps: S1, converting pyridine-4-butyric acid into piperidine-4-butyramide under the condition of ammonia gas; S2, enabling the piperidine-4-butyrylamide to react with pyridine, so as to generate pyridine-4-butyronitrile; S3, carrying out a reduction reaction on the pyridine-4-butyronitrile in an acid environment under the action of a catalyst to generate the piperidine-4-butylamine. According to the preparation method provided by the embodiment of the invention, the reaction steps are short, the safety of raw materials is high, and the experimental operability is very strong.
Synthesis and evaluation of halogenated dibenzodiazepines as muscarinic receptor ligands
Kassiou, Michael,Read, Roger W.,Shi, Xue-Qin
, p. 799 - 804 (2007/10/03)
Syntheses of four novel amide analogues of the muscarinic M2 receptor antagonists, DIBA and BIBN 140, are described from a common intermediate. Pharmacological evaluation through in vitro assays reveals high muscarinic receptor affinity in each of the compounds, but variable subtype selectivity, primarily M2 but in one case M3.
Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use
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, (2008/06/13)
The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a com